CAJ | 학술논문

随着青霉素等抗生素的问世，人类因细菌感染所致疾病的死亡率大为降低；但在抗生素广泛应用至今，我们又面临着细菌耐药日趋严重、耐药菌感染难以控制、新抗生素研发脚步迟滞的严峻局势。如何应对这一全球性的难题，研究者们殚精竭虑，力求在抗生素以外寻求新的突破，有着比抗生素更悠久历史、同样具有抗菌活性的细菌素引起了研究者们的重视。但抗菌谱、产量等问题使细菌素的应用受到了限制，打破瓶颈成了当下研究的热点。本文主要对细菌素的研究现状、应用及异源表达做了相关综述。
수착청매소등항생소적문세，인류인세균감염소치질병적사망솔대위강저；단재항생소엄범응용지금，아문우면림착세균내약일추엄중、내약균감염난이공제、신항생소연발각보지체적엄준국세。여하응대저일전구성적난제，연구자문탄정갈필，력구재항생소이외심구신적돌파，유착비항생소경유구역사、동양구유항균활성적세균소인기료연구자문적중시。단항균보、산량등문제사세균소적응용수도료한제，타파병경성료당하연구적열점。본문주요대세균소적연구현상、응용급이원표체주료상관종술。
With the advent of antibiotics such as penicillin, the mortality from bacterial infection has been greatly reduced. But decades later, after widespread application of antibiotics, we should deal with the severe situation that the antibiotic re-sistance is becoming increasingly serious, the infections from resistant strains are difficult to control and development of new antibiotics is rather slow.In order to overcome these problems, researchers are exploring new ways besides antibiotics, and pay more attentions to bacteriocins because of their antibacterial activities.But the applications of bacteriocins are also re-stricted by antibacterial spectrum, production and so on, and making a breakthrough becomes a hotspot.This review will focus on the status, application and heterologous expression of bacteriocins.