CAJ | 학술논문

目的：探讨复方威茯治疗痛风的作用。方法：采用微晶型尿酸钠（MSU）致兔子及大鼠急性痛风性关节炎的方法造模，造模后取兔子关节滑膜，观察其关节滑膜病理组织学变化，检测兔血清中肿瘤坏死因子（TNF-α）、白介素-1β（IL-1β）、白介素-6（IL-6）水平；测定造模后大鼠足肿胀度及MSU致炎足渗出液中前列腺素E2（PGE2）的含量，观察复方威茯的抗痛风作用。结果：复方威茯高、中剂量组滑膜组织血管充血、滑膜肿胀、炎性细胞浸润程度明显改善（P<0.05），血清中TNF-α、IL-1β、IL-6水平均明显下降（P<0.05或P<0.01），可明显抑制MSU所致的大鼠足肿胀度及炎足渗出液中PGE2生成（P<0.05或P<0.01）。结论：复方威茯有明显的治疗痛风作用。
목적：탐토복방위복치료통풍적작용。방법：채용미정형뇨산납（MSU）치토자급대서급성통풍성관절염적방법조모，조모후취토자관절활막，관찰기관절활막병리조직학변화，검측토혈청중종류배사인자（TNF-α）、백개소-1β（IL-1β）、백개소-6（IL-6）수평；측정조모후대서족종창도급MSU치염족삼출액중전렬선소E2（PGE2）적함량，관찰복방위복적항통풍작용。결과：복방위복고、중제량조활막조직혈관충혈、활막종창、염성세포침윤정도명현개선（P<0.05），혈청중TNF-α、IL-1β、IL-6수평균명현하강（P<0.05혹P<0.01），가명현억제MSU소치적대서족종창도급염족삼출액중PGE2생성（P<0.05혹P<0.01）。결론：복방위복유명현적치료통풍작용。
This article was aimed to study the action of antigout effects of compoundWeifu. Through the acute gouty arthritis models of rabbits and rats induced by micro-crystal sodium urate (MSU). The histopathological changes of synovial tissues among rabbits were observed. And the contents of TNF-α, IL-1β, IL-6 in rabbit serum were determined. The swelling degree of the rats’ feet and the content of prostaglandin E2 (PGE2) from the inflammatory exudate foot induced by MSU were also determined. The antigout effects of compoundWeifu were observed. The results showed that the grade of the vascular congestion, swelling and inflammatory cell infiltration in synovial tissues in the high-dose and medium-dose CompoundWeifu group had significantly improved (P <0.05). And the levels of TNF-α, IL-1β, IL-6 in serum were significantly decreased (P< 0.05, orP < 0.01). It can obviously reduce the swelling degree induced by MSU, and the level of PGE2 in the inflammatory exudate foot (P< 0.05, orP < 0.01). It was concluded that CompoundWeifu had obvious antigout effects in the study.