CAJ | 학술논문

目的：观察解毒通络胶囊对中风后抑郁大鼠行为学的影响，评价解毒通络胶囊益气解郁的功效。方法：大鼠麻醉后采用颈外动脉注射微球法制备多发性梗死模型，中长期饲养造成中风后抑郁模型，对各组大鼠进行旷场实验、悬尾实验、游泳实验不动时间测定、糖水偏好实验等行为学实验。结果：大鼠注射荧光微球后长期饲养形成中风后抑郁模型，与正常组相比，模型组大鼠进食量减少，体质量增加较缓，旷场实验所示的自发运动和探究活动减少，游泳不动时间、悬尾不动时间延长，糖水偏好程度下降。与模型组相比，解毒通络胶囊组及步长脑心通组大鼠体质量增幅较大，旷场实验所示的自发运动和探究活动增加，游泳不动时间和悬尾不动时间均缩短，糖水偏好程度增加，并接近假手术组。结论：解毒通络胶囊对中风后抑郁大鼠的抑郁样行为有显著改善作用。
목적：관찰해독통락효낭대중풍후억욱대서행위학적영향，평개해독통락효낭익기해욱적공효。방법：대서마취후채용경외동맥주사미구법제비다발성경사모형，중장기사양조성중풍후억욱모형，대각조대서진행광장실험、현미실험、유영실험불동시간측정、당수편호실험등행위학실험。결과：대서주사형광미구후장기사양형성중풍후억욱모형，여정상조상비，모형조대서진식량감소，체질량증가교완，광장실험소시적자발운동화탐구활동감소，유영불동시간、현미불동시간연장，당수편호정도하강。여모형조상비，해독통락효낭조급보장뇌심통조대서체질량증폭교대，광장실험소시적자발운동화탐구활동증가，유영불동시간화현미불동시간균축단，당수편호정도증가，병접근가수술조。결론：해독통락효낭대중풍후억욱대서적억욱양행위유현저개선작용。
This study was aimed to observe behavioral changes of post-stroke depression (PSD) rats, and to assess effect ofJie-Du Tong-Luo(JDTL) capsule onqi-supplementing and depression-relieving. Microspheres were injected from external carotid artery of rats under anesthesia to prepare the multiple cerebral infarction. Aftermid long term feeding, PSD rat model was established. Then, open-field test (OFT), tail suspension test (TST), forced swimming test (FST) and glucose preference test were employed to study behavioral changes of rats. The results showed that rats suffered multiple cerebral infarction after mid long term feeding formed PSD, which were indicated by reduced food consume, slow body weight increasing, reduction of spontaneous movement and inquiry activity, prolonged accumulative immobility time in TST, FST and lowered glucose preference, compared with rats in the normal group. Compared with the model group, rats in the JDTL capsule group andBu-Chang Xin-Nao-Tonggroup showed larger body weight increase, higher scores in OFT, reduced immobility time in TST, FST, and elevated glucose preference. It was concluded that JDTL capsule had significant efficacy on rats’ body weight, behavior and glucose preference, which might be its pharmacological basis onqi-supplementing and depression-relieving.