CAJ | 학술논문

目的：探讨新生儿早发型B族链球菌（GBS ）败血症的临床特点，提高对本病的认识。方法选取我院2010—2012年我院新生儿重症监护病房（NICU）收治的新生儿资料，回顾性分析 GBS 的临床表现、实验室检查、治疗和转归。结果早发型 GBS 败血症8例，占住院患儿的6.28‰，均为足月儿，生后24小时内发病，以气促、发绀等呼吸系统症状为主，其中4例出现感染性休克表现；实验室检查提示血常规 WBC：2.07～14.1×109／L，＜5×109／L 5例，中性粒细胞绝对值0.54～8.32×109／L。胸部 X 线提示：肺部纹理粗乱，渗出增多。1例需机械通气辅助呼吸。青霉素联合头孢三代或万古霉素治疗有效，重症感染者需加强支持治疗。结论应重视新生儿早发型无乳链球菌败血症早期呼吸系统症状，尽早诊断和治疗，降低病死率。
목적：탐토신생인조발형B족련구균（GBS ）패혈증적림상특점，제고대본병적인식。방법선취아원2010—2012년아원신생인중증감호병방（NICU）수치적신생인자료，회고성분석 GBS 적림상표현、실험실검사、치료화전귀。결과조발형 GBS 패혈증8례，점주원환인적6.28‰，균위족월인，생후24소시내발병，이기촉、발감등호흡계통증상위주，기중4례출현감염성휴극표현；실험실검사제시혈상규 WBC：2.07～14.1×109／L，＜5×109／L 5례，중성립세포절대치0.54～8.32×109／L。흉부 X 선제시：폐부문리조란，삼출증다。1례수궤계통기보조호흡。청매소연합두포삼대혹만고매소치료유효，중증감염자수가강지지치료。결론응중시신생인조발형무유련구균패혈증조기호흡계통증상，진조진단화치료，강저병사솔。
Objective To investigate the clinical features of early-on set neonatal Group B Streptococcal (GBS)septi-cemia in order to guide the clinical diagnosis and treatment. Methods Retrospectively analysing the clinical presentation,la-boratory examination,treatment and prognosis of the 8 cases of all newborns from 2010 to 2012 in our hospital. Results The incidence of neonatal early-on set Group B Streptococcal septicemia was 6.28‰.8 cases were full-term infants in this study.Re-spiratory symptoms such as anhelation and cyanosis were first signs of early-on set Group B streptococcal septicemia within 24 hours after birth;4 cases of septic shock.Results of laboratory tests included WBC:2.07 ~14.1 ×109 /L,in which 5 cases were <5 ×109 /L,N 0.54 ~8.32 ×109 /L.Chest X-ray:lung texture showed coarse and disorderly,leakage was increased.One case needed respiratory support with mechanical ventilation.Intravenous treatment of neonatal GBS with penicillin combined with Vancomycin was effective.Patients of serve infections should be provided supportive care. Conclusion Patients of serve early symptom of respiratory system should be paid attention.Early diagnosis and treatment should be as soon as possible to re-duce fatalities.