CAJ | 학술논문

目的：探讨磷酸化应激诱导蛋白1(stress induced phosphoprotein 1, STIP1)和雌激素受体-α(estrogen receptor-α, ER-α)蛋白在甲状腺乳头状癌中的表达及其相关性。方法收集甲状腺乳头状癌54例、淋巴结转移癌18例、桥本甲状腺炎15例、癌旁甲状腺组织10例。应用免疫组化SP法检测各组STIP1和ER-α蛋白的表达,分析二者与甲状腺乳头状癌临床病理特征的关系及其相关性。结果 STIP1和ER-α在甲状腺乳头状癌中的阳性率(55．6%、44．4%)高于正常甲状腺组织(10%、0)及桥本甲状腺炎组织(8．3%、0,P均<0．05)。乳头状癌组织中STIP1蛋白表达与淋巴结转移相关(P<0．05),ER-α蛋白表达与患者性别、TG-Ab值、是否合并结节性甲状腺肿相关(P均<0．05),与淋巴结转移无关(P>0．05)。 STIP1和ER-α蛋白表达与患者年龄、肿瘤部位、病灶数目、肿瘤大小、侵犯被膜、是否合并桥本甲状腺炎、TPO-Ab值均无关( P均>0．05)；STIP1与ER-α表达呈正相关(P<0．05)。结论 STIP1和ER-α蛋白可能参与促进甲状腺乳头状癌的淋巴结转移。
목적：탐토린산화응격유도단백1(stress induced phosphoprotein 1, STIP1)화자격소수체-α(estrogen receptor-α, ER-α)단백재갑상선유두상암중적표체급기상관성。방법수집갑상선유두상암54례、림파결전이암18례、교본갑상선염15례、암방갑상선조직10례。응용면역조화SP법검측각조STIP1화ER-α단백적표체,분석이자여갑상선유두상암림상병리특정적관계급기상관성。결과 STIP1화ER-α재갑상선유두상암중적양성솔(55．6%、44．4%)고우정상갑상선조직(10%、0)급교본갑상선염조직(8．3%、0,P균<0．05)。유두상암조직중STIP1단백표체여림파결전이상관(P<0．05),ER-α단백표체여환자성별、TG-Ab치、시부합병결절성갑상선종상관(P균<0．05),여림파결전이무관(P>0．05)。 STIP1화ER-α단백표체여환자년령、종류부위、병조수목、종류대소、침범피막、시부합병교본갑상선염、TPO-Ab치균무관( P균>0．05)；STIP1여ER-α표체정정상관(P<0．05)。결론 STIP1화ER-α단백가능삼여촉진갑상선유두상암적림파결전이。
Purpose To detect the expressions of stress induced phosphoprotein 1 (STIP1) and estrogen receptor-α(ER-α) in papil-lary thyroid carcinoma and to analyse the relationship between STIP1 and ER-α. Methods 54 cases of paraffin-embedded tissues of papillary thyroid carcinoma, 18 cases of papillary thyroid carcinoma with lymph node metastasis, 15 cases of Hashimoto’ s thyroiditis, 10 cases of adjacent normal thyroid tissue were collected. The expressions of STIP1 and ER-αwere detected by immunohistochemistry, and the relationship between the expressions and clinicopathological features of papillary thyroid carcinoma was analyzed. Results The expression of STIP1 and ER-α in papillary thyroid cancer group ( 55. 6% and 44. 4%) were higher than that of normal thyroid group (10% and 0) and Hashimoto’s thyroiditis group (8. 3% and 0, all P<0. 05). STIP1 expressions was related to lymph node metastasis ( P<0. 05 ) , while ER-α expression was related to gender, TG-Ab and the merger of nodular goiter, but not related to lymph node metastasis (P>0. 05). The expressions of STIP1 and ER-α in papillary thyroid carcinoma were not related to patients’ age , tumor location, number of tumors, tumer size, invasion of capsule, the concomitant Hashimoto’ s thyroiditis and TPO-Ab ( all P>0. 05). And the expressions of STIP1 was not related to gender, TG-Ab and the merger of nodular goiter (all P>0. 05). A positive correlation was found between the expressions of STIP1 and ER-αin thyroid papillary carcinoma (P<0. 05). Conclusion STIP1 and ER-α in papillary thyroid carcinoma may be related with lymph node metastasis.