CAJ | 학술논문

目的：探讨拉莫三嗪辅助帕罗西汀治疗难治性抑郁症的临床效果。方法114例难治性抑郁症患者随机分为研究组（帕罗西汀合并拉莫三嗪治疗）57例和对照组（单用帕罗西汀治疗）57例。于治疗前及治疗后第2、4、8周末采用汉密尔顿抑郁量表（ HAMD）及治疗中需处理的不良反应症状量表（ TESS）评定疗效及不良反应。结果两组治疗后第2、4、8周末HAMD评分较治疗前均降低（P＜0．05）。治疗后第4、8周末HAMD评分研究组低于对照组（P＜0．05）。治疗8周后研究组总有效率（82．5％）高于对照组（50．9％）（ P＜0．05）。研究组总不良反应发生率为（38．6％）与对照组（31．6％）比较差异无统计学意义（P＞0．05）。结论拉莫三嗪辅助帕罗西汀治疗难治性抑郁症疗效优于单用帕罗西汀治疗，且不增加不良反应发生率。
목적：탐토랍막삼진보조파라서정치료난치성억욱증적림상효과。방법114례난치성억욱증환자수궤분위연구조（파라서정합병랍막삼진치료）57례화대조조（단용파라서정치료）57례。우치료전급치료후제2、4、8주말채용한밀이돈억욱량표（ HAMD）급치료중수처리적불량반응증상량표（ TESS）평정료효급불량반응。결과량조치료후제2、4、8주말HAMD평분교치료전균강저（P＜0．05）。치료후제4、8주말HAMD평분연구조저우대조조（P＜0．05）。치료8주후연구조총유효솔（82．5％）고우대조조（50．9％）（ P＜0．05）。연구조총불량반응발생솔위（38．6％）여대조조（31．6％）비교차이무통계학의의（P＞0．05）。결론랍막삼진보조파라서정치료난치성억욱증료효우우단용파라서정치료，차불증가불량반응발생솔。
Objective To investigate the efficacy of lamotrigine as adjunctive therapy of paroxetine for the treatment of refractorydepression.Methods 115patientswithrefractorydepressionwererandomlydividedintostudygroup(57cases) treated with lamotrigine combined with paroxetine and control group (57 cases) treated with paroxetine monotherapy for 8 weeks. All patients were assessed with Hamilton Depression Scale ( HAMD) and Treatment Emergent Symptom Scale ( TESS) at baseline and at the end of the 2nd, 4th, 8th week of the treatment to evaluate the efficacy and the side effects respectively.Results Scores of HAMD in both groups decreased significantly at the end of the 2nd, 4th, 8th week when compared with the baseline (P<0.05).Scores of HAMD at the end of the 4th, 8th week in study group were significantly lower than those in control group (P<0.05).The response rate in study group was significantly higher than that in control group at the endpoint (82.5%vs.50.9%, P<0.05).There was no significant difference in incidence rate of adverse reactions between study group and control group (38. 6%vs.31.6%, P >0.05 ).Conclusion Lamotrigine combined with paroxetine has better efficacy than paroxetine monotherapy in the treatment of refractory depression, and it does not increase the incidence of adverse reactions.