世界科学技术-中医药现代化
世界科學技術-中醫藥現代化
세계과학기술-중의약현대화
World Science and Technology-Modernization of Traditional Chinese Medicine
2015年
7期
1392-1397
,共6页
洪晓华%任建勋%王杨慧%金龙%杨斌%董小霞%张伟%葛争艳%李宏坤%刘建勋
洪曉華%任建勛%王楊慧%金龍%楊斌%董小霞%張偉%葛爭豔%李宏坤%劉建勛
홍효화%임건훈%왕양혜%금룡%양빈%동소하%장위%갈쟁염%리굉곤%류건훈
芪术颗粒%糖尿病肾病%早期蛋白尿%证候
芪術顆粒%糖尿病腎病%早期蛋白尿%證候
기술과립%당뇨병신병%조기단백뇨%증후
Qi-Zhu granules%diabetic nephropathy%early proteinuria%syndrome
目的：观察芪术颗粒对糖尿病肾病气阴两虚、痰浊阻络证大鼠早期蛋白尿抑制作用。方法：44只大鼠随机分为空白组、模型组、黄葵胶囊组和芪术颗粒组。采用单侧肾结扎合并高热量胆固醇饮食同时复合低剂量链脲佐菌素腹腔注射的方法，建立糖尿病肾病气阴两虚、痰浊阻络证大鼠模型，连续给药8周，观察第4周后大鼠蛋白尿、尿肌酐以及实验结束后血糖、血脂、肝功能和肾脏病理结构的变化。结果：与模型组比较，芪术颗粒可以明显抑制糖尿病肾病早期蛋白尿，促进肌酐排泄，同时调节血脂代谢，保护肝功能，改善肾脏组织病理学变化。结论：芪术颗粒对糖尿病肾病气阴两虚、痰浊阻络证大鼠早期蛋白尿具有独立抑制作用，并不依赖于降血糖作用，体现了中药复方功效与病证的对应关系。
目的：觀察芪術顆粒對糖尿病腎病氣陰兩虛、痰濁阻絡證大鼠早期蛋白尿抑製作用。方法：44隻大鼠隨機分為空白組、模型組、黃葵膠囊組和芪術顆粒組。採用單側腎結扎閤併高熱量膽固醇飲食同時複閤低劑量鏈脲佐菌素腹腔註射的方法，建立糖尿病腎病氣陰兩虛、痰濁阻絡證大鼠模型，連續給藥8週，觀察第4週後大鼠蛋白尿、尿肌酐以及實驗結束後血糖、血脂、肝功能和腎髒病理結構的變化。結果：與模型組比較，芪術顆粒可以明顯抑製糖尿病腎病早期蛋白尿，促進肌酐排洩，同時調節血脂代謝，保護肝功能，改善腎髒組織病理學變化。結論：芪術顆粒對糖尿病腎病氣陰兩虛、痰濁阻絡證大鼠早期蛋白尿具有獨立抑製作用，併不依賴于降血糖作用，體現瞭中藥複方功效與病證的對應關繫。
목적：관찰기술과립대당뇨병신병기음량허、담탁조락증대서조기단백뇨억제작용。방법：44지대서수궤분위공백조、모형조、황규효낭조화기술과립조。채용단측신결찰합병고열량담고순음식동시복합저제량련뇨좌균소복강주사적방법，건립당뇨병신병기음량허、담탁조락증대서모형，련속급약8주，관찰제4주후대서단백뇨、뇨기항이급실험결속후혈당、혈지、간공능화신장병리결구적변화。결과：여모형조비교，기술과립가이명현억제당뇨병신병조기단백뇨，촉진기항배설，동시조절혈지대사，보호간공능，개선신장조직병이학변화。결론：기술과립대당뇨병신병기음량허、담탁조락증대서조기단백뇨구유독립억제작용，병불의뢰우강혈당작용，체현료중약복방공효여병증적대응관계。
ThisstudywasaimedtoobservetheinhibitoryeffectsofQi-Zhu (QZ)granulesonearlyproteinuria in diabetic nephropathy rats with syndrome of qi-yin deficiency and phlegm blocking collaterals. A total of 44 rats were randomly divided into the blank group, model group, Huang-Kui capsule group, QZ granules group. The rat model of diabetic nephropathy with syndrome of qi-yin deficiency and phlegm blocking collaterals was induced by the combination of unilateral renal artery ligation, diet of high-calorie and high cholesterol, and intraperitoneal injection of low-dose streptozotocin. The medication was given for 8 weeks. The concentrations of protein and creatinine in urine were observed on the 4th week. The blood glucose, blood lipids, liver function and renal pathological changes were observed at the end of the experiment. The results showed that compared with the model group, QZ granules can obvious suppress early proteinuria in diabetic nephropathy, promote creatinine excretion, regulate blood lipid metabolism, protect liver function and improve renal pathological changes. It was concluded that QZ granules had independent inhibition effect on early proteinuria in diabetic nephropathy rats with syndrome of qi-yin deficiency and phlegm blocking collaterals. The effect was independent of lowing blood glucose. It represented the corresponding relation between the syndrome and efficacy in Chinese herb compounds.
