CAJ | 학술논문

海洋中药是祖国中药宝库中的重要组成部分，是海洋经济发展的重要增长点之一。研究量效确切的海洋中药配伍，扩大海洋中药的临床应用，是现阶段海洋中药研究面临的重大问题。论文提出“文献检索-提取关于海洋中药方剂医案-建立医案数据库-数理统计与数据挖掘-构建药对博弈模型-研究固定剂量配比的药对功用”的研究构想，探索结合博弈理论研究海洋中药药对的新思路。通过文献检索和文本提取，获得应用龙骨牡蛎药对的病案458例，构建了合伙人博弈模型，采用严格下策反复消去法迭代剔除次优策略，假设龙牡等量使用且剂量30 g时为最佳策略，趋近纳什均衡。结果显示，30、25、24、20、18、15 g龙牡等量的剂量为可理性化的策略；30 g等量使用次数为数理统计频次之最；30 g龙牡等量使用时多取其重镇潜敛之功，对眠差、纳少、畏寒、耳鸣、神疲乏力、自汗盗汗等症状有治疗作用。关联规则分析、数理统计、博弈模型三方结果互为验证和补充，说明运用数理统计和数据挖掘技术、结合博弈论理论研究海洋中药药对思路具有可行性。
해양중약시조국중약보고중적중요조성부분，시해양경제발전적중요증장점지일。연구량효학절적해양중약배오，확대해양중약적림상응용，시현계단해양중약연구면림적중대문제。논문제출“문헌검색-제취관우해양중약방제의안-건립의안수거고-수리통계여수거알굴-구건약대박혁모형-연구고정제량배비적약대공용”적연구구상，탐색결합박혁이론연구해양중약약대적신사로。통과문헌검색화문본제취，획득응용용골모려약대적병안458례，구건료합화인박혁모형，채용엄격하책반복소거법질대척제차우책략，가설룡모등량사용차제량30 g시위최가책략，추근납십균형。결과현시，30、25、24、20、18、15 g룡모등량적제량위가이성화적책략；30 g등량사용차수위수리통계빈차지최；30 g룡모등량사용시다취기중진잠렴지공，대면차、납소、외한、이명、신피핍력、자한도한등증상유치료작용。관련규칙분석、수리통계、박혁모형삼방결과호위험증화보충，설명운용수리통계화수거알굴기술、결합박혁론이론연구해양중약약대사로구유가행성。
Marine medicine is an important part of Chinese medicine and a growth point of marine economy development.Exploration on the exact weight ratios and curative effect to expand marine medicine clinical application is a significant issue in marine medicine research at this stage. This paper presented a research supposition of“documents retrieval, extraction of marine medicine cases, establishment of case database, statistic analysis, data mining, herb pair Game Theory model establishment, herb pair usage under fixed dosage and matching, in order to explore a new idea of researching marine medicine combined with Game Theory. Through the literature retrieval and text extraction, 458 cases with the herb pair ofLong-Gu (LG) andMu-Li(ML) were received to establish the partnership game model. The iterative removals of strictly dominated strategies were adopted. Assuming that LG and ML used with an equal amount of 30 g was the best response, which reached the Nash equilibrium. The results suggested that dosages of LG and ML used equally at the amount of 30 g, 25 g, 24 g, 20 g, 18 g, 15 g were rationalizable strategies. Frequencies of using an equal amount of 30 g LG and ML was the most of mathematical statistics. LG and ML of 30 g were used equivalently to treat symptoms such as insomnia, inappetence, chills, tinnitus, physically and mentally fatigued, spontaneous sweating and night sweating, and so on with the effect of tranquilizing and constricting. The results can be validated and complemented among association rules analysis, mathematical statistics and game model. It implied that it was feasible to apply mathematical statistics and data mining in combination with Game Theory to study the marine medicine herb pair.