CAJ | 학술논문

目的：评价益气养阴活血方对糖尿病肾病(DN)患者临床终点事件的影响。方法回顾性采集并筛选2008年纳入观察周期6个月的DN临床随机对照研究的95例患者基线数据。试验组47例，长期采用益气养阴活血方为主的中西医综合干预方案进行治疗；对照组48例，长期采用单纯西医综合干预方案进行治疗。分别于2011、2012、2013、2014年进行4次随访，比较2组患者肾功能进展/死亡等终点事件的远期发生率。结果试验组死亡5例，其中1例为肾功能衰竭引起死亡；对照组死亡8例，其中5例因肾功能衰竭引发多脏器衰竭死亡。试验组进入终末期肾脏病、肾功能进展等终点事件的发生率明显低于对照组(P＜0.05)。结论以益气养阴活血方为主的中西医综合干预方案具有良好的保护肾功能作用，可以延缓DN患者进入终末期肾脏病的进程，改善DN的预后，疗效优于单纯西医综合干预方案。
목적：평개익기양음활혈방대당뇨병신병(DN)환자림상종점사건적영향。방법회고성채집병사선2008년납입관찰주기6개월적DN림상수궤대조연구적95례환자기선수거。시험조47례，장기채용익기양음활혈방위주적중서의종합간예방안진행치료；대조조48례，장기채용단순서의종합간예방안진행치료。분별우2011、2012、2013、2014년진행4차수방，비교2조환자신공능진전/사망등종점사건적원기발생솔。결과시험조사망5례，기중1례위신공능쇠갈인기사망；대조조사망8례，기중5례인신공능쇠갈인발다장기쇠갈사망。시험조진입종말기신장병、신공능진전등종점사건적발생솔명현저우대조조(P＜0.05)。결론이익기양음활혈방위주적중서의종합간예방안구유량호적보호신공능작용，가이연완DN환자진입종말기신장병적진정，개선DN적예후，료효우우단순서의종합간예방안。
Objective To evaluate the effects ofYiqi Yangyin Huoxue Formula on clinical endpoints of diabetic nephropathy patients.Methods Totally 95 patients who were involved into the six-month DN clinical RCT for observation in 2008 were retrospectively collected and screened. There are 47 cases in the trial group, who were chronically treated by integrated traditional Chinese and Western medicine therapy which mainly adoptingYiqi Yangyin Huoxue Formula. There were 48 cases in the control group, who were chronically treated with Western medicine. Follow-up visits were conducted in 2011, 2012, 2013, and 2014 respectively. Long-term incidence rate of renal function progress/deaths were compared in the two groups.Results Five cases died in the trial group, among which one case died of renal failure. Eight cases died in the control group, among which five died of renal failure and multiple organ failure. The incidence of endpoints entering end-stage renal disease and renal function progress was much lower than that of control group. Conclusion Integrated traditional Chinese and Western medicine therapy dominated byYiqi Yangyin Huoxue Formula has good clinical efficacy of kidney protection, and can slow the progress of DN patients entering end-stage renal disease, and better than single Western medicine intervention.