CAJ | 학술논문

目的：探讨急性脑梗死颈动脉斑块与基质金属蛋白酶(MMP)7、MMP-12及超敏C反应蛋白(hs-CRP)的关系。方法选取2014年6月~2015年3月本院收治的60例急性脑梗死患者作为观察组，选取同期的60例门诊体检健康者作为对照组，采用彩色多普勒超声检测仪进行颈动脉超声检查，同时检测血清MMP-7、MMP-12、hs-CRP水平，对两组的检测结果进行分析研究。结果观察组的血清hs-CRP、MMP-7、MMP-12水平显著高于对照组，差异有统计学意义(P<0.05)。颈部血管超声检测显示，无斑块病例16例(26.7%)，硬斑病例19例(30.0%)，混合斑病例13例(21.7%)，软斑病例12例(20.0%)。各组的hs-CRP水平比较，差异有统计学意义(P<0.05)。软斑组的hs-CRP水平显著高于其他3组，差异有统计学意义(P<0.05)。各组的MMP-7、MMP-12水平比较，差异有统计学意义(P<0.05)。混合斑组的MMP-7、MMP-12水平著高于其他3组，差异有统计学意义(P<0.05)。结论急性脑梗死与血清MMP-7、MMP-12及hs-CRP水平具有明显相关性。
목적：탐토급성뇌경사경동맥반괴여기질금속단백매(MMP)7、MMP-12급초민C반응단백(hs-CRP)적관계。방법선취2014년6월~2015년3월본원수치적60례급성뇌경사환자작위관찰조，선취동기적60례문진체검건강자작위대조조，채용채색다보륵초성검측의진행경동맥초성검사，동시검측혈청MMP-7、MMP-12、hs-CRP수평，대량조적검측결과진행분석연구。결과관찰조적혈청hs-CRP、MMP-7、MMP-12수평현저고우대조조，차이유통계학의의(P<0.05)。경부혈관초성검측현시，무반괴병례16례(26.7%)，경반병례19례(30.0%)，혼합반병례13례(21.7%)，연반병례12례(20.0%)。각조적hs-CRP수평비교，차이유통계학의의(P<0.05)。연반조적hs-CRP수평현저고우기타3조，차이유통계학의의(P<0.05)。각조적MMP-7、MMP-12수평비교，차이유통계학의의(P<0.05)。혼합반조적MMP-7、MMP-12수평저고우기타3조，차이유통계학의의(P<0.05)。결론급성뇌경사여혈청MMP-7、MMP-12급hs-CRP수평구유명현상관성。
Objective To explore the relationship between carotid plaque and matrix metalloproteinase 7 (MMP-7),ma-trix metalloproteinase 12 (MMP-12) and high-sensitivity C reactive protein (hs-CRP) in patients with acute cerebral infarction. Methods 60 patients with acute ischemic stroke from June 2014 to March 2015 in our hospital were select-ed as the observation group,60 healthy cases from outpatient were selected as the control group.Plaque of carotid artery were examined by colo Doppler,and the serum MMP-7,MMP-12 and hs-CRP levels were determined in all patient. Then the results of two groups was compared. Results The level of the serum MMP-7,MMP-12 and hs-CRP in the ob-servation group was higher than that in control group,with significant difference (P<0.05).The neck vascular ultrasound detection showed that 16 cases had no plaques,19 cases were hard plaques,13 cases were mixture plaques and 12 cases were soft plaques.The level of hs-CRP in each group was statistically significant (P<0.05).The level of hs-CRP in the soft plaque group was higher than that in the other 3 groups,with significant difference (P<0.05).The level of MMP-7, MMP-12 in each group was statistically significant (P<0.05).The level of hs-CRP in the mixed plaque group was higher than that in the other 3 groups,with significant difference (P<0.05). Conclusion Acute ischemic stroke has obvious cor-relation with the serum MMP-7,MMP-12 and hs-CRP levels.