CAJ | 학술논문

结肠定位给药系统随着药物制剂技术的提高逐渐向高效、低度、长效的方向发展，在结肠局部疾病的治疗中，对提高药物疗效、减少药物的副作用具有重要的临床意义。根据结肠生理结构特点可将结肠定位给药系统大致分为：pH依赖型给药系统、时间依赖型给药系统、压力控制型给药系统、酶解型给药系统。高新材料和定位技术的突破是结肠定位给药系统发展的驱动力。结肠定位给药系统作为高新的现代定位给药制剂具有重大的科研价值和广阔的市场价值。本文就国内外结肠定位给药系统的研究进展作一综述。
결장정위급약계통수착약물제제기술적제고축점향고효、저도、장효적방향발전，재결장국부질병적치료중，대제고약물료효、감소약물적부작용구유중요적림상의의。근거결장생리결구특점가장결장정위급약계통대치분위：pH의뢰형급약계통、시간의뢰형급약계통、압력공제형급약계통、매해형급약계통。고신재료화정위기술적돌파시결장정위급약계통발전적구동력。결장정위급약계통작위고신적현대정위급약제제구유중대적과연개치화엄활적시장개치。본문취국내외결장정위급약계통적연구진전작일종술。
Colonic drug delivery system developed towards efficient,low-grade,long-term with the improvement of the drug formulation technology and have important clinical implications in the treatment of localized disease of the colon, improving drug efficacy,reducing side effects.Colonic drug delivery system can be roughly divided into pH-dependent drug delivery systems,time-dependent delivery system,pressure-controlled drug delivery system and enzyme-type deliv-ery system according to the physical structure characteristics of the colon.Breakthrough in high-tech materials and posi-tioning technology is the driving force of development of colonic drug delivery system.Colonic drug delivery system is of great scientific value and broad market value as high-tech modern drug delivery formulations.This paper reviews the research progress of colonic drug delivery system both at home and abroad.