CAJ | 학술논문

目的：探讨白癜风患者血清中自身抗体和甲状腺激素的水平及临床意义。方法分别用间接免疫荧光法、免疫印迹法、化学发光法检测123例白癜风患者和60名正常对照者抗核抗体（ ANA ）、抗核抗体谱（ANAS）、游离三碘甲状腺原氨酸（ FT3）、游离甲状腺素（ FT4）、促甲状腺激素（ TSH）、甲状腺球蛋白抗体（ TG-Ab）和甲状腺过氧化物酶抗体（ TPO-Ab），并对白癜风组和正常对照组间的以上检测指标进行比较分析。结果白癜风组ANA、TG-Ab、TPO-Ab阳性率高于正常对照组（P均＜0．01）， ANAS阳性率2个组间比较差异无统计学意义（P＞0．05）；FT3、FT4水平2个组间比较差异无统计学意义（P均＞0．05），TSH水平白癜风组高于正常对照组（P＜0．05）。结论白癜风与甲状腺自身免疫性疾病之间关系密切， ANA、TG-Ab、TPO-Ab及TSH可作为白癜风患者伴有自身免疫性疾病的常用检测指标。
목적：탐토백전풍환자혈청중자신항체화갑상선격소적수평급림상의의。방법분별용간접면역형광법、면역인적법、화학발광법검측123례백전풍환자화60명정상대조자항핵항체（ ANA ）、항핵항체보（ANAS）、유리삼전갑상선원안산（ FT3）、유리갑상선소（ FT4）、촉갑상선격소（ TSH）、갑상선구단백항체（ TG-Ab）화갑상선과양화물매항체（ TPO-Ab），병대백전풍조화정상대조조간적이상검측지표진행비교분석。결과백전풍조ANA、TG-Ab、TPO-Ab양성솔고우정상대조조（P균＜0．01）， ANAS양성솔2개조간비교차이무통계학의의（P＞0．05）；FT3、FT4수평2개조간비교차이무통계학의의（P균＞0．05），TSH수평백전풍조고우정상대조조（P＜0．05）。결론백전풍여갑상선자신면역성질병지간관계밀절， ANA、TG-Ab、TPO-Ab급TSH가작위백전풍환자반유자신면역성질병적상용검측지표。
Objective To investigate the levels and clinical significance of serum autoantibodies and thyroid hormone in patients with vitiligo.Methods The anti-nuclear antibody ( ANA ) , anti-nuclear antibody spectrum (ANAS), free triiodothyronine (FT3), free thyroxine (FT4), thyroid stimulating hormone (TSH), thyroglobulin antibody ( TG-Ab) and thyroid peroxidase antibody ( TPO-Ab) were determined in 123 patients with vitiligo and 60 healthy controls by indirect immunofluorescence, immunoblotting and chemiluminescence.The determination items were statistically compared between vitiligo group and control group.Results The positive rates of ANA, TG-Ab and TPO-Ab in vitiligo group were higher than those in control group(P<0.01), while ANAS was not statistically significant between the 2 groups (P>0.05).FT3 and FT4 were not statistically significant in the 2 groups(P>0.05).TSH in vitiligo group was higher than that in control group (P<0.05).Conclusions The relationship is close between vitiligo and thyroid autoimmune diseases.ANA, TG-Ab, TPO-Ab and TSH determinations can be usually used in vitiligo patients with autoimmune diseases.