CAJ | 학술논문

目的评估组织声学结构定量技术( ASQ)与慢乙肝所致肝脏纤维化分级之间的关系. 方法对90例明确肝脏病理穿刺结果的慢乙肝患者及60例健康志愿者进行腹部常规超声检查和ASQ检查,收集图像,每一幅图像选定规定感兴趣区( ROI) ,用ASQ分析软件脱机分析,比较分析其χ2 直方图,计算红色曲线众数( Redmode )、红色曲线均值( Re-dave)、红色曲线标准差( Redsd)、蓝色曲线众数( Bluemode)、蓝色曲线均值( Blueave)、蓝色曲线标准差( Bluesd)及红蓝曲线下面积比( FD ratio). 比较相应肝脏穿刺结果,经统计分析后,研究各项参数与肝脏穿刺肝纤维化分级结果的统计学差异. 结果随着肝纤维化程度的增加,红蓝曲线分布由平滑、锐利变得粗糙、增宽,蓝色曲线下面积逐渐增大. 其中,Redmode在正常对照组与 S0-1、S1 组;S0-1 与 S1 组及S1-2与S2组之间差异无统计学意义,其余各组之间差异均有统计学意义(P<0. 01). Redave在正常对照组与S0-1、S1组;S0-1与S1组及S1-2与S2组、S2-3组之间差异无统计学意义,其余各组之间差异均有统计学意义. Redsd、Blue-mode、Blueave及FD ratio在正常对照、S0-1、S1、S1-2、S2与S3组间差异均有统计学意义(P<0. 05),Bluesd在任意两组间差异均无统计学意义. 结论 ASQ技术作为一项无创性评价肝纤维化程度的技术,其红蓝曲线χ2 直方图及7个参数值对肝纤维化分级的评估具有重要价值,其中, Redmode及Redave参数意义最大.
목적 평고조직성학결구정량기술( ASQ)여만을간소치간장섬유화분급지간적관계. 방법 대90례명학간장병리천자결과적만을간환자급60례건강지원자진행복부상규초성검사화ASQ검사,수집도상,매일폭도상선정규정감흥취구( ROI) ,용ASQ분석연건탈궤분석,비교분석기χ2 직방도,계산홍색곡선음수( Redmode )、홍색곡선균치( Re-dave)、홍색곡선표준차( Redsd)、람색곡선음수( Bluemode)、람색곡선균치( Blueave)、람색곡선표준차( Bluesd)급홍람곡선하면적비( FD ratio). 비교상응간장천자결과,경통계분석후,연구각항삼수여간장천자간섬유화분급결과적통계학차이. 결과 수착간섬유화정도적증가,홍람곡선분포유평활、예리변득조조、증관,람색곡선하면적축점증대. 기중,Redmode재정상대조조여 S0-1、S1 조;S0-1 여 S1 조급S1-2여S2조지간차이무통계학의의,기여각조지간차이균유통계학의의(P<0. 01). Redave재정상대조조여S0-1、S1조;S0-1여S1조급S1-2여S2조、S2-3조지간차이무통계학의의,기여각조지간차이균유통계학의의. Redsd、Blue-mode、Blueave급FD ratio재정상대조、S0-1、S1、S1-2、S2여S3조간차이균유통계학의의(P<0. 05),Bluesd재임의량조간차이균무통계학의의. 결론 ASQ기술작위일항무창성평개간섬유화정도적기술,기홍람곡선χ2 직방도급7개삼수치대간섬유화분급적평고구유중요개치,기중, Redmode급Redave삼수의의최대.
Objective Assess the relationship between acoustic structure quantification technology and the grade of liver fibrosis resulted from chronic hepatitis B. Methods 60 healthy volunteers and 90 patients with histologically proven chronic hepatitis B virus were examined by B-Mode ultrasound with ASQ software. Collectted images,select ROI specifically in each image. Then analyzed them with ASQ analysis software offline, compared analysis of theirχ2 histogram, calculated Redmode, Redave, Redsd, Bluemode, Blueave, Bluesd and FD ratio. Compared the cor-responding pathologic results of the liver biopsy. After statistical analysis, then examined the statistical differences between each parameter of ASQ and grade of pathologic result of liver fibrosis. Results Red histogram curve and blue histogram curve in the horizontal distribution were more rough, broader, the area under blue curve was much larger than the red as with the degree of liver fibrosis increased. Redmode showed a statistical difference between two groups (P<0. 01) except for the normal control group, S0-1 and S1 group, S0-1 and S1 group, S1-2 and S2 group;Redave showed a statistical difference between two groups (P<0. 05) except for the normal control group, S0-1 and S1 group, S0-1 and S1 group, S1-2 and S2 and S2-3 group;Redsd, Bluemode, Blueave and FD ratio all showed significant difference between the normal control group, S0-1, S1, S1-2, S2 group, S2-3 and S3 group (P<0. 05). There was no significant difference between any two groups in Bluesd. Conclusion As a noninvasive assessment of measuring liver fibrosis, ASQ technology's 7 parameters andχ2 parameter histograms of red and blue curves play an important role in regarding the grade of liver fibrosis,in which, Redmode and Redave show the grea-test significance.