安徽医科大学学报
安徽醫科大學學報
안휘의과대학학보
Acta Universitatis Medicinalis Anhui
2015年
10期
1493-1496
,共4页
结直肠癌%骨桥蛋白%免疫组织化学%预后
結直腸癌%骨橋蛋白%免疫組織化學%預後
결직장암%골교단백%면역조직화학%예후
colorectal cancer%osteopontin%immunohistochemistry%prognostic
目的 探讨骨桥蛋白( OPN)在结直肠癌组织中的表达与临床病理特征及预后的关系. 方法 应用免疫组化SP法测定112例结直肠癌患者癌组织及癌旁正常组织中OPN表达水平,分析OPN表达与结直肠癌患者临床病理特征及预后的关系. 结果 结直肠癌组织中OPN阳性表达率明显高于相应癌旁正常组织,差异有统计学意义(P<0. 05),其表达水平与肿瘤直径、分化程度、TNM分期、原发肿瘤浸润深度相关;OPN阳性表达组的无病生存时间和总体生存时间均短于阴性表达组,差异有统计学意义( P<0. 05 ). OPN的阳性表达是结直肠癌患者预后的独立影响因素. 结论结直肠癌患者癌组织中OPN呈高表达, OPN在组织中的高表达与患者的早期复发及不良预后密切相关.
目的 探討骨橋蛋白( OPN)在結直腸癌組織中的錶達與臨床病理特徵及預後的關繫. 方法 應用免疫組化SP法測定112例結直腸癌患者癌組織及癌徬正常組織中OPN錶達水平,分析OPN錶達與結直腸癌患者臨床病理特徵及預後的關繫. 結果 結直腸癌組織中OPN暘性錶達率明顯高于相應癌徬正常組織,差異有統計學意義(P<0. 05),其錶達水平與腫瘤直徑、分化程度、TNM分期、原髮腫瘤浸潤深度相關;OPN暘性錶達組的無病生存時間和總體生存時間均短于陰性錶達組,差異有統計學意義( P<0. 05 ). OPN的暘性錶達是結直腸癌患者預後的獨立影響因素. 結論結直腸癌患者癌組織中OPN呈高錶達, OPN在組織中的高錶達與患者的早期複髮及不良預後密切相關.
목적 탐토골교단백( OPN)재결직장암조직중적표체여림상병리특정급예후적관계. 방법 응용면역조화SP법측정112례결직장암환자암조직급암방정상조직중OPN표체수평,분석OPN표체여결직장암환자림상병리특정급예후적관계. 결과 결직장암조직중OPN양성표체솔명현고우상응암방정상조직,차이유통계학의의(P<0. 05),기표체수평여종류직경、분화정도、TNM분기、원발종류침윤심도상관;OPN양성표체조적무병생존시간화총체생존시간균단우음성표체조,차이유통계학의의( P<0. 05 ). OPN적양성표체시결직장암환자예후적독립영향인소. 결론결직장암환자암조직중OPN정고표체, OPN재조직중적고표체여환자적조기복발급불량예후밀절상관.
Objective To investigate the relationship between the osteopontin ( OPN ) expression of colorectal cancer tissues with the clinical characteristics and prognosis. Methods The expressions of OPN in colorectal cancer tissues and their corresponding para-cancerous tissues from 112 cases of colorectal cancer patients were detccted by immunohistochemistry . The relationship between the expressions of OPN and the clinicopathological features in pait-ients with colorectal cancer were analyzed. Results The OPN expression of colorectal cancer tissues was signifi-cantly higher than their corresponding adjacent normal tissues, the difference was statistically significant ( P <0. 05). Its expression was significantly associated with tumor size, histological differentiation, TNM stage, tumor status. Disease-free survival, and overall survival time of OPN protein positive expression group were lower than that of the negative group, respectively, the differences were statistically significant(P<0. 05). The expression of OPN in colorectal cancer tissues was an independent prognostic factor. Conclusion The expression of OPN is sig-nificantly increased in colorectal cancer tissues, and the positive expression of OPN is associated with the prognostic of patients with colorectal cancer.
