CAJ | 학술논문

人工合成的含非甲基化 CpG 基序的寡聚脱氧核苷酸（CpG ODN）能够与树突状细胞、B 细胞、单核细胞及巨噬细胞等免疫细胞内质网膜上的 Toll 样受体9（TLR-9）结合，通过产生 Th1型免疫反应和分泌促炎因子来增强免疫应答的强度，在机体抵抗病原入侵和抗肿瘤等方面起到免疫增强剂的作用。近年来， CpG ODN 作为一种新型免疫佐剂受到了人们越来越多的关注。论文主要介绍了 CpG ODN 的种类及其结构和功能特征、作用机制、对畜禽的免疫增强作用、安全性等方面的研究进展，为 CpG ODN 作为疫苗佐剂的进一步研究和在兽医临床上的应用提供参考。
인공합성적함비갑기화 CpG 기서적과취탈양핵감산（CpG ODN）능구여수돌상세포、B 세포、단핵세포급거서세포등면역세포내질망막상적 Toll 양수체9（TLR-9）결합，통과산생 Th1형면역반응화분비촉염인자래증강면역응답적강도，재궤체저항병원입침화항종류등방면기도면역증강제적작용。근년래， CpG ODN 작위일충신형면역좌제수도료인문월래월다적관주。논문주요개소료 CpG ODN 적충류급기결구화공능특정、작용궤제、대축금적면역증강작용、안전성등방면적연구진전，위 CpG ODN 작위역묘좌제적진일보연구화재수의림상상적응용제공삼고。
Synthetic oligodeoxynucleotides containing CpG motifs (CpG ODN)could combine with Toll-like receptor 9 (TLR-9)on endoplasmic reticulum from dendritic cells,B cells,monocytes and macrophages to mount an immune response characterized by the production of Th1 and proinflammatory cytokines,as an immune enhancer to resistance to pathogen invasion and antitumor in the hosts.In recent years,CpG ODN as a new immune adjuvant has received more attention.This article mainly introduced the research progress on the kinds of CpG ODN and its structure and function characteristics,mechanisms of action,immune en-hancement livestock and poultry in to strengthen and safety for CpG ODN as vaccine adjuvants to offer ref-erence to further research and its veterinary usage in clinic.