CAJ | 학술논문

血脑屏障是机体内的一种重要的屏障系统，它可以有选择地阻止某些物质进入大脑，从而保持中枢神经系统内环境的相对稳定，但这也成为药物治疗中枢神经系统疾病的重要制约因素。中药对多种中枢神经系统疾病均具有良好的疗效，这说明其有效成分可以透过血脑屏障或影响血脑屏障的功能。本文归纳和总结了目前中药作用于血脑屏障的药理和临床试验研究方面的文献资料并对此进行综述。
혈뇌병장시궤체내적일충중요적병장계통，타가이유선택지조지모사물질진입대뇌，종이보지중추신경계통내배경적상대은정，단저야성위약물치료중추신경계통질병적중요제약인소。중약대다충중추신경계통질병균구유량호적료효，저설명기유효성분가이투과혈뇌병장혹영향혈뇌병장적공능。본문귀납화총결료목전중약작용우혈뇌병장적약리화림상시험연구방면적문헌자료병대차진행종술。
Blood-brain barrier (BBB) is a kind of important barrier system in the body. It can have a choice to prevent certain substances from entering the brain, in order to maintain the relative stability of internal environment of the central nervous system (CNS). However, it also became an important restriction factor for the treatment of CNS diseases. Traditional Chinese medicine (TCM) had good curative effects on several kinds of CNS diseases, which illustrated that effective composition of TCM can pass through or influence the function of BBB. This paper summarized the research progress of literatures on current pharmacological and clinical trials for the effect of TCM on BBB.