CAJ | 학술논문

安宫牛黄丸是中国传统中药中急症用药，现广泛应用于脑血管疾病、脑膜炎、中毒性脑病、败血症及各种原因引起的热病神昏等，现代药理学研究显示其具有抗炎、改善脑循环、保护脑细胞并减轻其损伤及损伤后所引起的脑水肿的作用，此皆为其疗效机制的研究热点。本文通过对安宫牛黄丸中、西认识及其近年来治疗急性脑血管病临床及药理机制的概述，以期为该药的临床运用提供参考，并为进一步的深入研究提供新的思路及展望。
안궁우황환시중국전통중약중급증용약，현엄범응용우뇌혈관질병、뇌막염、중독성뇌병、패혈증급각충원인인기적열병신혼등，현대약이학연구현시기구유항염、개선뇌순배、보호뇌세포병감경기손상급손상후소인기적뇌수종적작용，차개위기료효궤제적연구열점。본문통과대안궁우황환중、서인식급기근년래치료급성뇌혈관병림상급약리궤제적개술，이기위해약적림상운용제공삼고，병위진일보적심입연구제공신적사로급전망。
An-Gong Niu-Huang (AGNH) Pill is an emergency medication in traditional Chinese medicine (TCM). It has been widely used in the treatment of cerebrovascular diseases, meningitis, toxic encephalopathy, hematosepsis, and various types of fever and coma. Pharmacological studies on AGNH Pill revealed that it had the effects of anti-inflammation, cerebral circulation improvement, brain cell protection, brain injury-reducing, and post-injury brain edema improvement. All these effects became the research hotspots in its therapeutic mechanism study. This article summarized the Chinese medicine and modern medicine understanding of AGNH Pill, its clinical application and pharmacological mechanism in the treatment of acute cerebrovascular diseases in recent years, in order to provide references for clinical practice as well as new thinking and prospect for further research.