CAJ | 학술논문

由于各种原因造成的骨缺损的修复是临床上一项具有挑战性的难题。自体骨移植被认为是理想的骨移植物，但是不可避免有其局限性：取骨区并发症和取骨量有限。伴随骨移植手术的增加对填充材料数量要求的激增，推动了合成骨填充材料的发展。可降解镁合金所具有的金属材料特性，其强度、塑性等都要远优于现已开始临床应用的钙磷陶瓷、硫酸钙和聚乳酸等可吸收材料，同时其弹性模量和密度更接近骨组织，因而具有在骨填充修复方面临床应用的优势和潜力。
유우각충원인조성적골결손적수복시림상상일항구유도전성적난제。자체골이식피인위시이상적골이식물，단시불가피면유기국한성：취골구병발증화취골량유한。반수골이식수술적증가대전충재료수량요구적격증，추동료합성골전충재료적발전。가강해미합금소구유적금속재료특성，기강도、소성등도요원우우현이개시림상응용적개린도자、류산개화취유산등가흡수재료，동시기탄성모량화밀도경접근골조직，인이구유재골전충수복방면림상응용적우세화잠력。
Bone defects are very challenging in orthopedic practice. There are many practical and clinical shortcomings in the repair of the defects by using autografts, allografts or xenografts, which continues to motivate the search for better alternatives. Magnesium-based metals have been increasingly studied in the past decade, and most studies are involved in their potential to be used as biodegradable implants due to their bio-compatibility combined with outstanding physical and mechanical properties. Their mechanical strength, degradation rate and bio-compatibility are taken as predominant advantages compared with commercialized bone substitutes. Thus, biodegradable Mg-based metals can be potential candidates as bone graft substitutes for future orthopaedic applications.