CAJ | 학술논문

目的：探讨2011年4月至2015年4月基础和临床研究关于棘皮动物微管相关类蛋白4与间变性淋巴瘤激酶（EML4-ALK）融合基因在肺腺癌中的表达特点及临床意义。方法通过万方医学网和贵州省数字图书馆数据库文献法查询，对5年来发表在国内的有关EML4-ALK的文献进行收集整理和分析。结果共收集符合纳入标准文献21篇，研究病例2550例，总结发现在肺腺癌中，EML4-ALK的检出率为9.61%，不同检测方法检出结果存在一定差异。结论 EML4-ALK在肺腺癌中呈低表达趋势，与肺腺癌的发生、发展有关，可作为新的治疗靶点，但检测方法仍需进一步研究和优化。
목적：탐토2011년4월지2015년4월기출화림상연구관우극피동물미관상관류단백4여간변성림파류격매（EML4-ALK）융합기인재폐선암중적표체특점급림상의의。방법통과만방의학망화귀주성수자도서관수거고문헌법사순，대5년래발표재국내적유관EML4-ALK적문헌진행수집정리화분석。결과공수집부합납입표준문헌21편，연구병례2550례，총결발현재폐선암중，EML4-ALK적검출솔위9.61%，불동검측방법검출결과존재일정차이。결론 EML4-ALK재폐선암중정저표체추세，여폐선암적발생、발전유관，가작위신적치료파점，단검측방법잉수진일보연구화우화。
Objective To investigate the expression and significance of echinoderm microtubule-associated protein-like 4 (EML4-ALK) fusion gene in lung adenocarcinoma through basal and clinical research in the recent five years. Methods The research was conducted through Wanfang Medicine Net and digital library data base of Guizhou to collect and analyze the documents published in China about EML4-ALK in the recent five years. Results There were 21 documents meeting inclusion criteria and 2 550 cases were studied. In summary, it was found out that detection rate of EML4-ALK in lung adenocarcinoma was 9.61%, With different testing method to measure the results there exist certain differences. Conclusion EML4-ALK showed a trend of lower expression in lung adenocarcinoma, associated with the occurrence and development of lung adenocarcinoma, it can be regarded as the new target spot. The detection method needs to be studied and optimized.