CAJ | 학술논문

肿瘤细胞的快速增值与代谢对铁的需求远高于正常细胞，缩氨基硫脲类铁螯合剂可以通过与铁的螯合作用，剥夺肿瘤生长必需的这个营养成分，进而达到抑制肿瘤细胞增值的目的，成为新一代抗肿瘤药物。对铁与肿瘤的关系，缩氨基硫脲类的抗肿瘤作用机制及这类药物目前的研究概况作综述。
종류세포적쾌속증치여대사대철적수구원고우정상세포，축안기류뇨류철오합제가이통과여철적오합작용，박탈종류생장필수적저개영양성분，진이체도억제종류세포증치적목적，성위신일대항종류약물。대철여종류적관계，축안기류뇨류적항종류작용궤제급저류약물목전적연구개황작종술。
Rapid proliferation and metabolite of tumor cells have a higher requirement for iron than normal cells. Because of chelation with iron, thiosemicarbazone iron chelators can deplete iron which is a necessary nutrition for tumor growth, to inhibit the growth of tumor and become a new generation of antitumor agents. This article reviews the relation of iron and tumor, antitumor mechanisms of thiosemicarbazone and advances research on thiosemicarbazone as potent antitumor agents.