海南医学
海南醫學
해남의학
Hainan Medical Journal
2015年
18期
2681-2683
,共3页
牙周炎%肾病%清肿瘤坏死因子-α%白细胞介素-8
牙週炎%腎病%清腫瘤壞死因子-α%白細胞介素-8
아주염%신병%청종류배사인자-α%백세포개소-8
Periodontitis%Nephropath%Tumor necrosis factor-α(TNF-α)%Interleukin-8 (IL-8)
目的：观察伴有慢性牙周炎的IgA肾病患者牙周治疗前后血清肿瘤坏死因子-α(TNF-α)和白细胞介素-8(IL-8)变化。方法选取伴有慢性牙周炎的IgA肾病患者50例(治疗组)和健康者30例(对照组)。对照组不予特殊处理，治疗组采用超声洁牙和VECTOR牙周治疗仪进行牙周治疗，对照组于初诊时，治疗组于治疗前及治疗后4周，分别检测两组受试者的牙周指数和血清TNF-α与IL-8的浓度。血清中TNF-α与IL-8的浓度采用酶联免疫吸附法测定。结果治疗组患者经过牙周治疗后，牙周状况明显好转，血清TNF-α与IL-8浓度与治疗前比较均明显降低，差异均有统计学意义(P<0.05)，但是牙周指数、TNF-α和IL-8浓度仍高于对照组，差异均有统计学意义(P<0.05)。结论牙周治疗不仅可以有效改善牙周组织的病变，利于牙周炎的恢复，而且可降低血清中细胞因子TNF-α、IL-8的水平，有助于对IgA肾病患者肾病的治疗。
目的：觀察伴有慢性牙週炎的IgA腎病患者牙週治療前後血清腫瘤壞死因子-α(TNF-α)和白細胞介素-8(IL-8)變化。方法選取伴有慢性牙週炎的IgA腎病患者50例(治療組)和健康者30例(對照組)。對照組不予特殊處理，治療組採用超聲潔牙和VECTOR牙週治療儀進行牙週治療，對照組于初診時，治療組于治療前及治療後4週，分彆檢測兩組受試者的牙週指數和血清TNF-α與IL-8的濃度。血清中TNF-α與IL-8的濃度採用酶聯免疫吸附法測定。結果治療組患者經過牙週治療後，牙週狀況明顯好轉，血清TNF-α與IL-8濃度與治療前比較均明顯降低，差異均有統計學意義(P<0.05)，但是牙週指數、TNF-α和IL-8濃度仍高于對照組，差異均有統計學意義(P<0.05)。結論牙週治療不僅可以有效改善牙週組織的病變，利于牙週炎的恢複，而且可降低血清中細胞因子TNF-α、IL-8的水平，有助于對IgA腎病患者腎病的治療。
목적：관찰반유만성아주염적IgA신병환자아주치료전후혈청종류배사인자-α(TNF-α)화백세포개소-8(IL-8)변화。방법선취반유만성아주염적IgA신병환자50례(치료조)화건강자30례(대조조)。대조조불여특수처리，치료조채용초성길아화VECTOR아주치료의진행아주치료，대조조우초진시，치료조우치료전급치료후4주，분별검측량조수시자적아주지수화혈청TNF-α여IL-8적농도。혈청중TNF-α여IL-8적농도채용매련면역흡부법측정。결과치료조환자경과아주치료후，아주상황명현호전，혈청TNF-α여IL-8농도여치료전비교균명현강저，차이균유통계학의의(P<0.05)，단시아주지수、TNF-α화IL-8농도잉고우대조조，차이균유통계학의의(P<0.05)。결론아주치료불부가이유효개선아주조직적병변，리우아주염적회복，이차가강저혈청중세포인자TNF-α、IL-8적수평，유조우대IgA신병환자신병적치료。
Objective To examine the levels of serum tumor necrosis factor-α(TNF-α) and interleukin-8 (IL-8) for IgA nephropathy patients with periodontitis before and after periodontal therapy. Methods Fifty pa-tients of IgA nephropathy with chronic periodontitis (study group) and 30 healthy individuals (control group) were in-cluded in this study. The study group was treated by ultrasonic and VECTOR periodontal therapy apparatus, whereas the control group received no special treatment. We measured the periodontal indexes, and serum TNF-αand IL-8 lev-els by enzyme-linked immunosorbent assay (ELISA) at the visit of doctor in the control group as well as before treat-ment and 4 weeks after treatment in the study group. Results After periodontal therapy, the periodontal status was significantly improved, with the levels of periodontal indexes and serum TNF-α and IL-8 significantly decreased. Compared with the control group, the periodontal indexes and the serum TNF-αand IL-8 were still significantly higher. Conclusion Periodontal treatment can not only effectively improve the periodontal lesions and promote the recovery of periodontitis, but also reduce the levels of serum TNF-αand IL-8 and benefit the treatment for IgA nephropathy.
