CAJ | 학술논문

目的：探讨超敏C反应蛋白（hs-CRP）、凝血三项（凝血酶原时间PT、活化部分凝血活酶时间APTT、纤维蛋白原FIB）指标在慢性乙肝肝硬化诊断与治疗中的应用价值。方法选取本院临床确诊的肝硬化患者62例，作为观察组；选取同期的62名健康体检者作为对照组。检测其CRP、PT、APTT、FIB水平，对测定结果在慢性乙肝肝硬化诊断与治疗中的价值进行比较和分析。结果观察组较对照组C反应蛋白明显升高，差异有统计学意义（P＜0.01）；其PT、APTT均较对照组延明显长（P＜0.01）；而FIB较对照组明显降低（P＜0.01）。结论肝硬化患者血清中hs-CRP水平明显升高，且有明显的凝血功能障碍，二者的联合检测对肝硬化患者进行更准确的病情判断、更好的监测和治疗具有重要意义。
목적：탐토초민C반응단백（hs-CRP）、응혈삼항（응혈매원시간PT、활화부분응혈활매시간APTT、섬유단백원FIB）지표재만성을간간경화진단여치료중적응용개치。방법선취본원림상학진적간경화환자62례，작위관찰조；선취동기적62명건강체검자작위대조조。검측기CRP、PT、APTT、FIB수평，대측정결과재만성을간간경화진단여치료중적개치진행비교화분석。결과관찰조교대조조C반응단백명현승고，차이유통계학의의（P＜0.01）；기PT、APTT균교대조조연명현장（P＜0.01）；이FIB교대조조명현강저（P＜0.01）。결론간경화환자혈청중hs-CRP수평명현승고，차유명현적응혈공능장애，이자적연합검측대간경화환자진행경준학적병정판단、경호적감측화치료구유중요의의。
Objective To investigate the application value of CRP, PT, APTT and FIB in the diagnosis and treatment of patients with chronic hepatitis B cirrhosis. Methods 62 cases of patients diagnosed cirrhosis were collected as the observation group, and 62 healthy subjects in the same period were collected as control group. The CRP, PT, APTT and FIB levers were detected and their signiifcance in the diagnosis and treatment of cirrhosis were compared and analyzed. Results Compared with the control group, the CRP lever in the observation group was significantly higher (P<0.01), PT, APTT in the observation group were signiifcantly prolonged (P<0.01) ,and the FIB lever was lower (P<0.01). Conclusion The combined determination of the tests are clinically significant to the judgment of disease conditions, monitoring of the changes and the treatment in patients with liver cirrhosis.