CAJ | 학술논문

目的：探讨诱导型一氧化氮合酶（iNOS）蛋白在鼻咽癌组织的表达以及与鼻咽癌的临床参数的关系。方法采用免疫组织化学方法对30例鼻咽部正常黏膜组织，115例鼻咽癌患者组织中的iNOS蛋白的表达情况进行检测，使用受试者工作特征曲线（ROC）预测iNOS表达在鼻咽癌中的诊断价值。分析iNOS在鼻咽癌中的诊断价值及iNOS与性别、年龄、病理类型、淋巴结转移、临床分期、复发等临床病理参数的关系。结果在鼻咽癌组织中，iNOS的阳性表达率为57.4%，与正常鼻咽部黏膜组织的阳性表达率（16.7%）相比，差异有统计学意义（P<0.01）。使用ROC研究iNOS对于鼻咽癌的诊断价值，发现曲线下面积为0.704[95%CI（0.605，0.802），P=0.01]。在鼻咽癌组织中，iNOS与年龄（r=0.269，P=0.004），淋巴结转移（r=0.242，P=0.009），临床分期（r=0.282，P=0.002）呈正相关。结论 iNOS对鼻咽癌的诊断具有一定的价值，并与鼻咽癌的转移、临床分期密切有关。
목적：탐토유도형일양화담합매（iNOS）단백재비인암조직적표체이급여비인암적림상삼수적관계。방법채용면역조직화학방법대30례비인부정상점막조직，115례비인암환자조직중적iNOS단백적표체정황진행검측，사용수시자공작특정곡선（ROC）예측iNOS표체재비인암중적진단개치。분석iNOS재비인암중적진단개치급iNOS여성별、년령、병리류형、림파결전이、림상분기、복발등림상병리삼수적관계。결과재비인암조직중，iNOS적양성표체솔위57.4%，여정상비인부점막조직적양성표체솔（16.7%）상비，차이유통계학의의（P<0.01）。사용ROC연구iNOS대우비인암적진단개치，발현곡선하면적위0.704[95%CI（0.605，0.802），P=0.01]。재비인암조직중，iNOS여년령（r=0.269，P=0.004），림파결전이（r=0.242，P=0.009），림상분기（r=0.282，P=0.002）정정상관。결론 iNOS대비인암적진단구유일정적개치，병여비인암적전이、림상분기밀절유관。
Objective To explore the expression of inducible nitric oxide synthase(iNOS) protein and its clinical relationship in nasopharyngeal carcinoma(NPC) tissues. Methods Immunohistochemistry(IHC) was used to detect iNOS protein expression in normal nasopharyngeal tissues(n=30) and NPC tissues(n=115). The relationship between iNOS and several parameters was analyzed, including gender, age, pathology type, lymphatic metastasis, clinical stage, recurrence and so on. The diagnostic value of iNOS for NPC was carried out by using receiver operating characteristic curve (ROC). Results The positive expression of iNOS in normal tissues and NPC was 16.7% and 57.4%, respectively, with a significant difference (P<0.01). The area under curve of iNOS to diagnose NPC was 0.704 [(95%CI(0.605,0.802), P=0.01]. In NPC, iNOS was positively correlated with age (r=0.269, P=0.004), lymphatic metastasis (r=0.242, P=0.009) and clinical stage (r=0.282, P=0.002). Conclusion iNOS has certain value in the diagnosis of NPC and it is closely related to the metastasis and clinical stage.