CAJ | 학술논문

目的：研究不同自主神经干预方法对家犬交感神经系统的影响。方法40只成年家犬随机分为肾交感神经消融(RSD)组(n=8)、低强度耳缘迷走神经刺激(LL-TS)组(n=8)、低强度颈动脉窦压力感受器刺激(LL-CBS)组(n=8)、低强度脊髓神经刺激(LL-SCS)组(n=8)和对照组(n=8)。分别在基础状态、干预1 h、2 h和3 h末测定同等电压强度高频电刺激左侧星状神经节（LSG）时的血压变化，并以血压变化最大值代表LSG功能。在基础状态和干预3 h末测定LSG神经活性和血浆去甲肾上腺素(NE)水平。结果基础状态时，对照组与RSD、LL-TS、LL-CBS和LL-SCS各干预组高频刺激LSG时诱导的血压变化最大值、LSG神经活性和血浆NE水平比较差异均无统计学意义(P>0.05)。干预3 h后，RSD、LL-TS、LL-CBS和LL-SCS各干预组LSG功能、神经活性和血浆NE水平均比对照组明显降低，差异均有统计学意义(P<0.05)。结论 RSD、LL-TS、LL-CBS和LL-SCS这几种自主神经干预方法都可以显著抑制LSG的功能和活性以及系统交感神经活性。
목적：연구불동자주신경간예방법대가견교감신경계통적영향。방법40지성년가견수궤분위신교감신경소융(RSD)조(n=8)、저강도이연미주신경자격(LL-TS)조(n=8)、저강도경동맥두압력감수기자격(LL-CBS)조(n=8)、저강도척수신경자격(LL-SCS)조(n=8)화대조조(n=8)。분별재기출상태、간예1 h、2 h화3 h말측정동등전압강도고빈전자격좌측성상신경절（LSG）시적혈압변화，병이혈압변화최대치대표LSG공능。재기출상태화간예3 h말측정LSG신경활성화혈장거갑신상선소(NE)수평。결과기출상태시，대조조여RSD、LL-TS、LL-CBS화LL-SCS각간예조고빈자격LSG시유도적혈압변화최대치、LSG신경활성화혈장NE수평비교차이균무통계학의의(P>0.05)。간예3 h후，RSD、LL-TS、LL-CBS화LL-SCS각간예조LSG공능、신경활성화혈장NE수평균비대조조명현강저，차이균유통계학의의(P<0.05)。결론 RSD、LL-TS、LL-CBS화LL-SCS저궤충자주신경간예방법도가이현저억제LSG적공능화활성이급계통교감신경활성。
Objective To investigate the effects of different autonomic nervous intervention on the sympa-thetic nerve system in dogs. Methods Forty dogs were randomly divided into the renal sympathetic nerve denerva-tion (RSD) group (n=8), the low-level tragus stimulation (LL-TS) group (n=8), the low-level carotid baroreceptor stim-ulation (LL-CBS) group (n=8), the low-level spinal cord stimulation (LL-SCS) group (n=8) and the control group (n=8). Blood pressure (BP) at baseline and 1 h, 2 h, 3 h after stimulation were recorded, and the maximum BP increasing value when high frequency stimulation (HFS) was delivered to left stellate ganglion were measured as the function of the left stellate ganglion. The nerve activity of LSG and the NE level of plasma were also measured. Results At baseline state, there were no significant differences between the control group and RSD group, LL-TS groups, LL-CBS group, LL-SCS group in the maximum BP increasing value, the LSG activity and the NE level (P>0.05). After 3 hours of auto-nomic intervention, the maximum BP increasing value, the LSG activity and the NE level of RSD group, LL-TS group, LL-CBS group, LL-SCS group were significantly lower than those of the control group. Conclusion Autonomic inter-vention by RSD, LL-TS, LL-CBS and LL-SCS could significantly decrease the activity and function of left stellate ganglion and the activity of systematic sympathetic nerve.