中国当代医药
中國噹代醫藥
중국당대의약
China Modern Medicine
2015年
25期
90-92
,共3页
纳美芬%儿童%重症手足口病%效果
納美芬%兒童%重癥手足口病%效果
납미분%인동%중증수족구병%효과
Nalmefene%Children%Severe hand-foot-mouth disease%Effect
目的：探讨盐酸纳美芬治疗重症儿童手足口病中的临床效果。方法选取本院2013年3~7月收治的220例重症手足口病患儿作为研究对象，随机分为观察组(112例)和对照组(108例)。对照组给予常规喜炎平抗病毒、脱水降颅压、控制液体入量等对症治疗，观察组在对照组的基础上给予盐酸纳美芬。比较两组的急性期症状改善时间、影像学结果及住院时间，观察两组治疗过程中有无过敏、腹泻等不良反应。结果观察组的总有效率显著高于对照组，差异有统计学意义(P<0.05)。观察组的体温控制、呼吸改善、易惊消失、呕吐缓解、意识障碍恢复时间及住院时间显著短于对照组，差异有统计学意义(P<0.01)。观察组的影像学异常发生率显著低于对照组，差异有统计学意义(P<0.05)。两组治疗过程中均未发生药物性皮疹、过敏性休克、腹泻等严重不良反应。结论盐酸纳美芬治疗儿童重症手足口病效果显著，可以明显改善患儿的临床症状，缩短住院时间，值得临床推广应用。
目的：探討鹽痠納美芬治療重癥兒童手足口病中的臨床效果。方法選取本院2013年3~7月收治的220例重癥手足口病患兒作為研究對象，隨機分為觀察組(112例)和對照組(108例)。對照組給予常規喜炎平抗病毒、脫水降顱壓、控製液體入量等對癥治療，觀察組在對照組的基礎上給予鹽痠納美芬。比較兩組的急性期癥狀改善時間、影像學結果及住院時間，觀察兩組治療過程中有無過敏、腹瀉等不良反應。結果觀察組的總有效率顯著高于對照組，差異有統計學意義(P<0.05)。觀察組的體溫控製、呼吸改善、易驚消失、嘔吐緩解、意識障礙恢複時間及住院時間顯著短于對照組，差異有統計學意義(P<0.01)。觀察組的影像學異常髮生率顯著低于對照組，差異有統計學意義(P<0.05)。兩組治療過程中均未髮生藥物性皮疹、過敏性休剋、腹瀉等嚴重不良反應。結論鹽痠納美芬治療兒童重癥手足口病效果顯著，可以明顯改善患兒的臨床癥狀，縮短住院時間，值得臨床推廣應用。
목적：탐토염산납미분치료중증인동수족구병중적림상효과。방법선취본원2013년3~7월수치적220례중증수족구병환인작위연구대상，수궤분위관찰조(112례)화대조조(108례)。대조조급여상규희염평항병독、탈수강로압、공제액체입량등대증치료，관찰조재대조조적기출상급여염산납미분。비교량조적급성기증상개선시간、영상학결과급주원시간，관찰량조치료과정중유무과민、복사등불량반응。결과관찰조적총유효솔현저고우대조조，차이유통계학의의(P<0.05)。관찰조적체온공제、호흡개선、역량소실、구토완해、의식장애회복시간급주원시간현저단우대조조，차이유통계학의의(P<0.01)。관찰조적영상학이상발생솔현저저우대조조，차이유통계학의의(P<0.05)。량조치료과정중균미발생약물성피진、과민성휴극、복사등엄중불량반응。결론염산납미분치료인동중증수족구병효과현저，가이명현개선환인적림상증상，축단주원시간，치득림상추엄응용。
Objective To explore the clinical efficacy of nalmefene hydrochloride in the treatment of children with se-vere hand-foot-mouth disease (HFMD). Methods 220 children with severe HFMD from March to July 2013 in our hospital were selected and randomly divided into the observation group (n=112) and the treatment group (n=108).The control group was given symptomatic treatments such as Xiyanping for antivirus,dehydration for reducing the intracra-nial pressure,and controlling fluid intake,the observation group was given nalmefene hydrochloride on the basis of the control group.The time of symptoms improvement at acute stage,imaging outcomes,and hospital stay in two groups was compared.The adverse reactions including allergy and diarrhea was observed in the process of treatment. Results The total effective rate in the observation group was higher than that in the control group,with significant difference (P<0.05).The time of temperature control,improvement of breathing,disappearance of shiver with terror,remission of vomit-ing, consciousness recovery and hospital stay in the treatment group was shorter than that in the control group,with sig-nificant difference (P<0.01).The incidence rateof imaging abnormalities in the observation group was lower than that in the control group,with significant difference (P<0.05).There was no severe adverse reaction like drug-induced rash,ana-phylactic shock,or diarrhea occurred in two groups during treatment. Conclusion The effect of nalmefene hydrochloride in the treatment of children with severe HFMD is significant,which can improve clinical manifestations and shorten hospital stay,it is worthy of clinical promotion and application.
