CAJ | 학술논문

目的：观察盐酸青藤碱注射液关节腔注射治疗膝骨关节炎急性疼痛的效果。方法选择2012年3月~2013年3月本院风湿免疫科膝关节炎患者40例，随机分为试验组和对照组，每组20例，对照组口服非甾体抗炎药及改善病情药物，试验组除基础治疗外进行膝关节定点穿刺后注入盐酸青藤碱注射液50 mg，1次/d，5 d为1个疗程。两组均于治疗前及治疗后6 d、治疗后1个月行视觉模拟评分法(VAS)、压痛、肿胀及功能障碍观察指标评分。结果 VAS评分：治疗后6 d试验组、对照组分别为(3.15±0.60)、(4.10±0.75)分(P<0.05)；治疗后1个月试验组、对照组分别为(1.90±0.76)、(2.60±0.88)分(P<0.05)。肿胀指数评分：治疗后1个月试验组、对照组分别为(0.90±0.91)、(1.80±0.89)分(P<0.01)。压痛指数评分：治疗后1个月试验组、对照组分别为(0.60±0.60)、(2.00±0.65)分(P<0.01)。功能障碍指数评分：治疗后1个月试验组、对照组分别为(0.80±0.74)、(2.10±0.81)分(P<0.01)。两组血常规、肝肾功能无明显变化。结论盐酸青藤碱注射液关节腔注射治疗可作为膝骨关节炎急性疼痛的有效措施。
목적：관찰염산청등감주사액관절강주사치료슬골관절염급성동통적효과。방법선택2012년3월~2013년3월본원풍습면역과슬관절염환자40례，수궤분위시험조화대조조，매조20례，대조조구복비치체항염약급개선병정약물，시험조제기출치료외진행슬관절정점천자후주입염산청등감주사액50 mg，1차/d，5 d위1개료정。량조균우치료전급치료후6 d、치료후1개월행시각모의평분법(VAS)、압통、종창급공능장애관찰지표평분。결과 VAS평분：치료후6 d시험조、대조조분별위(3.15±0.60)、(4.10±0.75)분(P<0.05)；치료후1개월시험조、대조조분별위(1.90±0.76)、(2.60±0.88)분(P<0.05)。종창지수평분：치료후1개월시험조、대조조분별위(0.90±0.91)、(1.80±0.89)분(P<0.01)。압통지수평분：치료후1개월시험조、대조조분별위(0.60±0.60)、(2.00±0.65)분(P<0.01)。공능장애지수평분：치료후1개월시험조、대조조분별위(0.80±0.74)、(2.10±0.81)분(P<0.01)。량조혈상규、간신공능무명현변화。결론염산청등감주사액관절강주사치료가작위슬골관절염급성동통적유효조시。
Objective To observe the effect of intra-articular cavity injection of Sinome nine hydrochloride for acute pain of knee osteoarthritis. Methods 40 patients with knee osteoarthritis from March 2012 to March 2013 in rheuma-toid immunology of our hospital were divided into study group and control group randomly,20 patients in each group,the control group was treated with non-steroidal anti-inflammatory drug orally and the drugs which could improve the con-dition,the study group injected Sinomenine hydrochloride injection 50 mg,once a day,5 days for a course.After knee point puncture except for basic treatment.Both groups scored by visual analog scale (VAS),tenderness,swelling and dys-function and other observation indexes 6 days before and after treatments and one month after treatments. Results VAS scores of study group and control group were (3.15±0.60) points and (4.10±0.75) points(P<0.05) respectively 6 days af-ter treatments;(1.90±0.76)points and (2.60±0.88) points (P<0.05)respectively one month after treatments.Swelling index scores of the study group and the control group were(0.90±0.91) points and(1.80±0.89) points(P<0.01) respectively one month after treatments.Tenderness index scores of the study group and the control group were (0.60±0.60) points and (2.00±0.65) points (P<0.01) respectively one month after treatments.Dysfunction index scores of study group and control group were (0.80±0.74) points and (2.10±0.81) points (P<0.01) respectively one month after treatments.Routine blood test,liver and kidney function between two groups had no significant changes. Conclusion Intra-articular cavity injec-tion of Sinome nine hydrochloride is an effective treatment for acute pain of knee osteoarthritis.