CAJ | 학술논문

褪黑素是大脑松果体腺、视交叉上核(suprachiasmatic nucleus，SNC)及周围组织合成分泌的一种吲哚类神经内分泌激素，具有抗氧化、抗炎、抗凋亡、阻滞钙离子通道和镇痛等广泛的生物学作用。近年来研究发现，褪黑素对糖尿病等代谢性疾病并发神经系统病变具有一定保护作用。本文就褪黑素对糖尿病神经系统并发症的保护作用及其机制研究进展做简要综述。
퇴흑소시대뇌송과체선、시교차상핵(suprachiasmatic nucleus，SNC)급주위조직합성분비적일충신타류신경내분비격소，구유항양화、항염、항조망、조체개리자통도화진통등엄범적생물학작용。근년래연구발현，퇴흑소대당뇨병등대사성질병병발신경계통병변구유일정보호작용。본문취퇴흑소대당뇨병신경계통병발증적보호작용급기궤제연구진전주간요종술。
Melatonin (N-acetyl-5-methoxytryptamine), a natural hormone secreted by the pineal gland, the suprachiasmatic nucleus (SNC) and the surrounding tissue, has extensive biological functions, such as antioxidant, anti-inflammatory, antiapoptosis, blocking calcium ion channels and analgesic. In recent years, the research reports that melatonin has certain protective effects on neurological complications induced by metabolic diseases, like diabetes. hTe present review summarizes the research progress the protective effects and mechanisms of melatonin in neurological complications of diabetes.