CAJ | 학술논문

我国鲍曼不动杆菌对临床常用抗生素的耐药情况严重，尤其近五年对碳青霉烯类抗菌药物耐药率逐年增高，进一步探讨耐药性增强的原因以及耐药菌株的流行传播有助于控制耐药的严重局面。整合子作为一种新的可移动基因元件，不仅能够捕获耐药基因组成耐药基因盒，而且与耐药基因水平传播密切相关，在鲍曼不动杆菌的耐药机制中发挥关键作用。本文就鲍曼不动杆菌整合子在国内外流行、表达情况与耐药方面的作用进行综述。
아국포만불동간균대림상상용항생소적내약정황엄중，우기근오년대탄청매희류항균약물내약솔축년증고，진일보탐토내약성증강적원인이급내약균주적류행전파유조우공제내약적엄중국면。정합자작위일충신적가이동기인원건，불부능구포획내약기인조성내약기인합，이차여내약기인수평전파밀절상관，재포만불동간균적내약궤제중발휘관건작용。본문취포만불동간균정합자재국내외류행、표체정황여내약방면적작용진행종술。
hTe resistance of Acinetobacter baumannii to a wide range of clinical antibiotics is a severe problem in China, especially the resistance rate of A. baumannii isolates to carbopenems has been increasing in recent 5 years. Making a further investigation on the reasons for the increasing rate of resistance and the epidemiological spread of drug-resistant strains contributes to controlling the severe situation of resistance. Integron, as a new mobile gene element, not only able to capture resistance genes to compose resistance gene cassettes, but also closely related to the horizontal transmission of resistance genes, which plays a lead role in mechanisms of resistance among clinical isolates of A. baumannii. hTis review emphasizes on the prevalence, characterization and effect of integrons among isolates of A. baumannii both in China and abroad.