化学研究与应用
化學研究與應用
화학연구여응용
Chemical Research and Application
2015年
9期
1403-1406
,共4页
Biginelli-like反应%3,4-二氢嘧啶-2(1H)-酮%硫酸钾%一锅法
Biginelli-like反應%3,4-二氫嘧啶-2(1H)-酮%硫痠鉀%一鍋法
Biginelli-like반응%3,4-이경밀정-2(1H)-동%류산갑%일과법
Biginelli-like reaction%3,4-dihydropyrimidin-2(1H)-ones%potassium sulfate%one-pot synthesis
以无水硫酸钾为催化剂,环己烷为溶剂,芳香醛、芳香酮和脲三组分“一锅法”合成了一系列5-未取代3,4-二氢嘧啶-2(1H)-酮化合物。与传统方法相比,该方法具有溶剂无毒、产率高、反应条件温和、催化剂价廉等优点。
以無水硫痠鉀為催化劑,環己烷為溶劑,芳香醛、芳香酮和脲三組分“一鍋法”閤成瞭一繫列5-未取代3,4-二氫嘧啶-2(1H)-酮化閤物。與傳統方法相比,該方法具有溶劑無毒、產率高、反應條件溫和、催化劑價廉等優點。
이무수류산갑위최화제,배기완위용제,방향철、방향동화뇨삼조분“일과법”합성료일계렬5-미취대3,4-이경밀정-2(1H)-동화합물。여전통방법상비,해방법구유용제무독、산솔고、반응조건온화、최화제개렴등우점。
An efficient and facile synthesis of 5-unsubstituted 3,4-dihydropyrimidin-2(1H)-ones via a Biginelli-like reaction of aro-matic aldehydes,aromatic ketone and urea in the presence of anhydrous K2 SO4 in cyclohexane using a heating method had been de-veloped. Compared with the classical reaction conditions,this synthetic method had the advantages of nontoxic solvent,moderate to high yields,mild reaction conditions,and inexpensive catalyst.
