临床与病理杂志
臨床與病理雜誌
림상여병리잡지
International Journal of Pathology and Clinical Medicine
2015年
9期
1643-1647
,共5页
妊娠期急性脂肪肝%诊断%治疗%人工肝支持系统
妊娠期急性脂肪肝%診斷%治療%人工肝支持繫統
임신기급성지방간%진단%치료%인공간지지계통
acute fatty liver of pregnancy%diagnosis%management%artiifcial liver support system
目的：探讨妊娠期急性脂肪肝(acute fatty liver of pregnancy，AFLP)的早期诊断及治疗，以降低孕产妇及围生儿的病死率。方法：对我院2011年1月至2015年1月收治的15例急性脂肪肝患者进行回顾性研究。结果：15例患者均发生于妊娠晚期，初产妇12例，经产妇3例，单胎13例，双胎2例，男胎12例，女胎5例，13例患者出现恶心，呕吐，厌食等症状。7例并发妊娠期高血压疾病。9例血糖降低，平产1例，剖宫产14例，入院至分娩时间为0.5~21.5 h。产后出血2例,无子宫切除。孕产妇死亡为0例，新生儿轻度窒息1例，死胎3例。结论：早期诊断，尽快终止妊娠是改善母儿预后的关键；多科协作，综合治疗，适时人工肝替代治疗，能有效提高产妇的生存率。
目的：探討妊娠期急性脂肪肝(acute fatty liver of pregnancy，AFLP)的早期診斷及治療，以降低孕產婦及圍生兒的病死率。方法：對我院2011年1月至2015年1月收治的15例急性脂肪肝患者進行迴顧性研究。結果：15例患者均髮生于妊娠晚期，初產婦12例，經產婦3例，單胎13例，雙胎2例，男胎12例，女胎5例，13例患者齣現噁心，嘔吐，厭食等癥狀。7例併髮妊娠期高血壓疾病。9例血糖降低，平產1例，剖宮產14例，入院至分娩時間為0.5~21.5 h。產後齣血2例,無子宮切除。孕產婦死亡為0例，新生兒輕度窒息1例，死胎3例。結論：早期診斷，儘快終止妊娠是改善母兒預後的關鍵；多科協作，綜閤治療，適時人工肝替代治療，能有效提高產婦的生存率。
목적：탐토임신기급성지방간(acute fatty liver of pregnancy，AFLP)적조기진단급치료，이강저잉산부급위생인적병사솔。방법：대아원2011년1월지2015년1월수치적15례급성지방간환자진행회고성연구。결과：15례환자균발생우임신만기，초산부12례，경산부3례，단태13례，쌍태2례，남태12례，녀태5례，13례환자출현악심，구토，염식등증상。7례병발임신기고혈압질병。9례혈당강저，평산1례，부궁산14례，입원지분면시간위0.5~21.5 h。산후출혈2례,무자궁절제。잉산부사망위0례，신생인경도질식1례，사태3례。결론：조기진단，진쾌종지임신시개선모인예후적관건；다과협작，종합치료，괄시인공간체대치료，능유효제고산부적생존솔。
Objective:To explore the early diagnosis and management of acute fatty liver of pregnancy (AFLP) so as to improve maternal and fetal survival. Methods:The clinical findings and outcomes of pregnancy were retrospectively analyzed in 15 patients with AFLP in this hospital from January 2011 to January 2015. Results:A total of 15 AFLP manifested in the third trimester, 12 of whom were nulliparas and 3 of whom were multiparas;13 of whom were singleton pregnancy and 2 of whom were twin pregnancy. There were total 17 fetuses, 12 of whom were males and 5 of whom were females. There were 7 patients with hypertension, 9 with lower blood glucose levels, and 13 with symptoms, including nausea, vomiting and anorexia. hTe duration from admission to fetal delivery was 0.5~21.5 hours. All patients preserved their uteri, with 14 patients ending the pregnancy with cesarean section and 1 with vaginal delivery. Two patients were complicated with postpartum hemorrhage. hTere was no maternal death. Fourteen newborns were normal, 1 was asphyxia and 3 were fetal deaths. Conclusion:hTe key to improving the prognosis of both mothers and fetuses is to make early diagnosis and to end the pregnancy timely. Multimodality therapy with the help of multiple departments and the artiifcial liver support system timely are effcient in reducing the maternal mortality.
