CAJ | 학술논문

目的：研究FoxQ1在食管鳞状细胞癌组织中的表达及其与临床病理特征和预后的关系。方法：在组织水平，应用免疫组织化学En Vision法检测91例食管鳞状细胞癌组织及相应癌旁组织FoxQ1的表达，并分析其表达与临床病理特征及预后之间的关系。结果：1) FoxQ1在食管鳞状细胞癌组织及配对正常食管组织中的阳性表达率分别为：62.6%(57/91)和23.1%(21/91)，差异有统计学意义(P<0.05)；FoxQ1的表达与肿瘤浸润深度、临床分期及预后相关(P<0.05)。经Kaplan-Meier法生存比较，FoxQ1的阳性表达者比阴性表达者生存期短(P<0.05)；多因素Cox比例风险模型分析显示，FoxQ1可以作为判断食管鳞状细胞癌预后的独立因素(P<0.05)。结论：FoxQ1在食管鳞状细胞癌组织中高表达，其表达水平与食管鳞癌发生发展及预后密切相关。有望成为评估食管鳞状细胞癌预后的有效指标。
목적：연구FoxQ1재식관린상세포암조직중적표체급기여림상병리특정화예후적관계。방법：재조직수평，응용면역조직화학En Vision법검측91례식관린상세포암조직급상응암방조직FoxQ1적표체，병분석기표체여림상병리특정급예후지간적관계。결과：1) FoxQ1재식관린상세포암조직급배대정상식관조직중적양성표체솔분별위：62.6%(57/91)화23.1%(21/91)，차이유통계학의의(P<0.05)；FoxQ1적표체여종류침윤심도、림상분기급예후상관(P<0.05)。경Kaplan-Meier법생존비교，FoxQ1적양성표체자비음성표체자생존기단(P<0.05)；다인소Cox비례풍험모형분석현시，FoxQ1가이작위판단식관린상세포암예후적독립인소(P<0.05)。결론：FoxQ1재식관린상세포암조직중고표체，기표체수평여식관린암발생발전급예후밀절상관。유망성위평고식관린상세포암예후적유효지표。
Objective:To investigate the expression of FoxQ1 in esophageal squamous cell carcinoma (ESCC) and analyze their clinical signiifcance, and to evaluate the correlation with prognosis. Methods:Immuno-histochemical method was used to detect the expression of FoxQ1 in 91 cases of ESCC tissues and adjacent normal esophageal tissues.χ2 test was used to analyze their correlations with the clinicopathologic factors and prognosis of ESCC patients. Results:hTe expression of FoxQ1 was signiifcantly higher in ESCC than that in normal esophageal tissues (62.6%vs 23.1%, P<0.05). FoxQ1 expression had signiifcantly correlations with invasive depth, clinical stage and prognosis (P<0.05). hTe results of Kaplan-Meier survival analysis indicated that positive expression of FoxQ1 were associated with a worse survival (P<0.05). Conclusion:FoxQ1 was highly expressed in ESCC and signiifcantly correlated with prognosis of esophageal cancer;FOXQ1 might be an indicator to predict the prognosis in esophageal cancer.