CAJ | 학술논문

目的：评价外周血和胸腔积液中N末端B型利钠肽(NT-proBNP)在胸腔积液患者中诊断心力衰竭的价值。方法：检测59例心力衰竭患者、11例结核性胸腔积液患者、31例肺炎性胸腔积液患者和36例恶性肿瘤性胸腔积液患者外周血和胸腔积液中的NT-proBNP水平，采用受试者工作特征曲线法(ROC)评价了外周血和胸腔积液中NT-proBNP对心力衰竭的诊断价值，分析了外周血和胸腔积液中NT-proBNP的相关性以及二者与患者纽约心脏病学会心功能分级(New York Heart Association， NYHA)的关系。结果：心衰患者外周血和胸腔积液中的NT-proBNP水平较非心衰患者明显增高。外周血和胸腔积液中NT-proBNP诊断心衰的曲线下面积分别为0.94和0.93。胸腔积液和外周血NT-proBNP确诊心衰的最佳界值是2800 pg/mL，排除心衰的最佳界值为900 pg/mL。胸腔积液和外周血NT-proBNP呈正相关，相关系数为0.91。胸腔积液和外周血中NT-proBNP均随着NYHA分级的递进而增加。结论：胸腔积液和外周血中NT-proBNP是诊断心衰的有益标志物。
목적：평개외주혈화흉강적액중N말단B형리납태(NT-proBNP)재흉강적액환자중진단심력쇠갈적개치。방법：검측59례심력쇠갈환자、11례결핵성흉강적액환자、31례폐염성흉강적액환자화36례악성종류성흉강적액환자외주혈화흉강적액중적NT-proBNP수평，채용수시자공작특정곡선법(ROC)평개료외주혈화흉강적액중NT-proBNP대심력쇠갈적진단개치，분석료외주혈화흉강적액중NT-proBNP적상관성이급이자여환자뉴약심장병학회심공능분급(New York Heart Association， NYHA)적관계。결과：심쇠환자외주혈화흉강적액중적NT-proBNP수평교비심쇠환자명현증고。외주혈화흉강적액중NT-proBNP진단심쇠적곡선하면적분별위0.94화0.93。흉강적액화외주혈NT-proBNP학진심쇠적최가계치시2800 pg/mL，배제심쇠적최가계치위900 pg/mL。흉강적액화외주혈NT-proBNP정정상관，상관계수위0.91。흉강적액화외주혈중NT-proBNP균수착NYHA분급적체진이증가。결론：흉강적액화외주혈중NT-proBNP시진단심쇠적유익표지물。
Objective:The aim of this study was to evaluate the diagnostic value of blood and pleural fluid (PF) NT-proBNP for patients with heart failure (HF). Methods:Blood and PF NT-proBNP levels in 59 patients with HF, 11 patients with tuberculosis, 31 patients with parapneumonic effusion and 36 patients with malignancy were measured. hTe diagnostic value of blood and PF NT-proBNP for HF was evaluated by a receiver operating characteristic (ROC) curve analysis. The relationship between blood and PF NT-proBNP, as well as The New York Heart Association (NYHA) functional classiifcation system, was analyzed. Results:Both blood and PF NT-proBNP were signiifcantly increased in HF patients. hTe area under ROC curve (AUC) for blood and PF NT-proBNP were 0.94 and 0.93, respectively. hTe optimal threshold used for ruling in and ruling out HF were 2 800 and 900 pg/mL. Blood and PF NT-proBNP were positively correlated, with a coefficient of 0.91, respectively.Both blood and PF NT-proBNP were increased with the advance of NYHA functional classification system. Conclusion:Both blood and PF NT-proBNP are useful diagnostic marker for HF in patients with PF.