CAJ | 학술논문

青蒿素是我国于20世纪70年代发现的抗疟活性成分。为满足不同的用药需要，研究人员近年来对其化学结构进行了改造，获得了系列青蒿素类衍生物，并根据药物的理化性质和实际临床需求，研制出了多种青蒿素类抗疟制剂，其中常用的制剂有片剂、栓剂和注射剂等。随着制剂技术不断发展，技术人员针对青蒿素类的纳米注射剂、经皮制剂和黏膜给药制剂等新剂型进行了大量研究。本文根据不同的给药途径，对近年来青蒿素类抗疟制剂的研究情况进行系统的整理和论述。
청호소시아국우20세기70년대발현적항학활성성분。위만족불동적용약수요，연구인원근년래대기화학결구진행료개조，획득료계렬청호소류연생물，병근거약물적이화성질화실제림상수구，연제출료다충청호소류항학제제，기중상용적제제유편제、전제화주사제등。수착제제기술불단발전，기술인원침대청호소류적납미주사제、경피제제화점막급약제제등신제형진행료대량연구。본문근거불동적급약도경，대근년래청호소류항학제제적연구정황진행계통적정리화논술。
Artemisinin is the antimalarial active ingredient, which is discovered by Chinese scientists in 1970s. The chemical structure of artemisinin is modified or altered to obtain a series of analogues to satisfy the medication requirements. According to the physicochemical properties of medicines and actual clinical necessities, the preparations of artemisinins are developed and the common preparations include tablet, suppository, injection, etc.. With the developing of technology, researchers have conducted a large number of studies on the artemisinins nanoparticles injection, transdermal drug delivery systems, mucosal drug delivery systems and etc. This article systematically collected and discussed the recent studies on the antimalarial preparations of artemisinins in line with different administration routes.