CAJ | 학술논문

目的：探讨附子不同炮制品灌胃Beagle犬的急性毒性。方法：取健康、合格Beagle犬16只，按体质量随机分为空白组、刨附片组、炮天雄组和黑顺片组。以4 g生药/kg灌胃给药，实验前及给药后1 h、24 h和第3、7、14天测定体质量、耗食量、肛温、心电图及血常规、血生化。结果：3个实验组Beagle犬在给药后均精神萎靡，血液电解质有显著性差异，其中黑顺片组最明显；刨附片组犬的红细胞、血糖和甘油三酯有显著性差异；炮天雄组犬的淋巴细胞和血糖有显著性差异，而黑顺片给药后犬的淋巴细胞显著降低。结论：3个炮制品毒性大小依次为黑顺片>刨附片>炮天雄。
목적：탐토부자불동포제품관위Beagle견적급성독성。방법：취건강、합격Beagle견16지，안체질량수궤분위공백조、포부편조、포천웅조화흑순편조。이4 g생약/kg관위급약，실험전급급약후1 h、24 h화제3、7、14천측정체질량、모식량、항온、심전도급혈상규、혈생화。결과：3개실험조Beagle견재급약후균정신위미，혈액전해질유현저성차이，기중흑순편조최명현；포부편조견적홍세포、혈당화감유삼지유현저성차이；포천웅조견적림파세포화혈당유현저성차이，이흑순편급약후견적림파세포현저강저。결론：3개포제품독성대소의차위흑순편>포부편>포천웅。
This article was aimed to study the acute toxicities on intragastric administration of differentRadix Aconiti Lateralis Praeparataprocessed products to Beagle dogs. A total of 16 healthy and qualified Beagle dogs were randomly divided into the blank group,Pao-Fu-Pian(PFP) group,Pao-Tian-Xiong(PTX) group andHei-Shun-Pian(HSP) group according to the body weight. The intragastric administration of 4 g crude herb per kg was given. Before medication, 1 h, 24 h, and 3, 7, 14 days after medication, the body weight, food consumption, rectal temperature, electrocardiogram, blood routine and blood biochemistry were measured. The results showed that after medication, all dogs in three experimental groups were depressed. And there were significant differences in the electrolytes of blood. Among them, the HSP group was the most obvious one. The red blood cells, blood sugar and triglycerides of dogs in the PFP group had significant difference. The lymphocytes and blood sugar had significant difference of dogs in the PTX group. However, after the medication of HSP, the lymphocytes of the dogs were decreased significantly. It was concluded that the toxicity of three processed products followed the order of HSP > PFP > PTX.