CAJ | 학술논문

辅助性T细胞(helper T cell,Th)9细胞是近年新发现的一种CD4+T细胞亚群,特异性分泌白细胞介素9( IL-9)。 Th9细胞的诱导分化受到多种细胞因子与转录因子的影响,且与其他T细胞亚群间存在相互影响。 IL-4和转化生长因子β是诱导其分化的关键细胞因子,PU.1和干扰素调节因子4为调节其分化的重要转录因子。 Th9细胞在炎症性疾病与肿瘤的发生、发展中发挥着重要作用,其生物学效应具有双向性,研究Th9细胞的分化发育及其在相关疾病中的具体作用,将为疾病的诊断治疗等提供新的线索。
보조성T세포(helper T cell,Th)9세포시근년신발현적일충CD4+T세포아군,특이성분비백세포개소9( IL-9)。 Th9세포적유도분화수도다충세포인자여전록인자적영향,차여기타T세포아군간존재상호영향。 IL-4화전화생장인자β시유도기분화적관건세포인자,PU.1화간우소조절인자4위조절기분화적중요전록인자。 Th9세포재염증성질병여종류적발생、발전중발휘착중요작용,기생물학효응구유쌍향성,연구Th9세포적분화발육급기재상관질병중적구체작용,장위질병적진단치료등제공신적선색。
Helper T cell (Th)9 cells,a new subset of CD4 + T cells,are characterized by the secretion of interleukin 9(IL-9). Many cytokines,transcription factors and the interaction of other CD4 + T cells play important roles in the differentiation of Th9 cells. IL-4 and TGF-β are the key cytokines to induce its differ-entiation,PU. 1 and IRF4 are the main transcription factors to regulate its differentiation. Th9 cells involve in the development of the inflammatory diseases and tumors with bidirectional role. A better understanding of the differentiation and function of Th9 cells may provide insights into new diagnosis and therapeutic targets for the diseases.