医药前沿
醫藥前沿
의약전연
Yiayao Qianyan
2015年
25期
129-130,131
,共3页
<35岁孕妇%孕中期%DS筛查风险值%不良妊娠结局
<35歲孕婦%孕中期%DS篩查風險值%不良妊娠結跼
<35세잉부%잉중기%DS사사풍험치%불량임신결국
Pregnant women aged < 35%The second trimester%DS risk value via serum screening%Adverse pregnancy outcomes
目的：探讨＜35岁孕妇孕中期血清学筛查唐氏综合征（(Down syndrome，DS)）风险值与不良妊娠结局发生的关系，评价D S筛查风险值对不良妊娠结局的预测价值。方法：选择2014年1月到2014年12月在我们产前筛查门诊进行孕中期血清学筛查DS高风险、中风险、低风险预产期年龄＜35周岁单胎妊娠孕妇各562例，观察三组孕妇发生妊娠合并贫血、妊娠期高血压疾病、妊娠期糖尿病、胎盘异常、羊水过少等内容；观察三组围产儿发生早产儿、胎儿宫内发育迟缓、胎儿宫内窘迫、新生儿室息、围产儿死亡等内容。结果：DS筛查高风险孕妇与中风险孕妇发生妊娠期高血压疾病、羊水过少、胎儿宫内窘迫间比较差异有统计学意义（P＜0.05）；D S筛查高风险孕妇与低风险孕妇发生妊娠合并贫血、妊娠期高血压疾病、妊娠期糖尿病、胎盘异常、羊水过少、胎儿宫内窘迫、新生儿室息间比较差异有统计学意义（P＜0.01，P＜0.05）；D S筛查中风险孕妇与低风险孕妇发生胎盘异常、新生儿室息间比较差异有统计学意义（P＜0.05）。结论：＜35岁孕妇孕中期血清学筛查D S风险值与不良妊娠结局发生的关系密切，如能加强对DS筛查高风险、中风险孕妇及其围产儿的监测和管理，可降低不良妊娠结局的发生。
目的：探討＜35歲孕婦孕中期血清學篩查唐氏綜閤徵（(Down syndrome，DS)）風險值與不良妊娠結跼髮生的關繫，評價D S篩查風險值對不良妊娠結跼的預測價值。方法：選擇2014年1月到2014年12月在我們產前篩查門診進行孕中期血清學篩查DS高風險、中風險、低風險預產期年齡＜35週歲單胎妊娠孕婦各562例，觀察三組孕婦髮生妊娠閤併貧血、妊娠期高血壓疾病、妊娠期糖尿病、胎盤異常、羊水過少等內容；觀察三組圍產兒髮生早產兒、胎兒宮內髮育遲緩、胎兒宮內窘迫、新生兒室息、圍產兒死亡等內容。結果：DS篩查高風險孕婦與中風險孕婦髮生妊娠期高血壓疾病、羊水過少、胎兒宮內窘迫間比較差異有統計學意義（P＜0.05）；D S篩查高風險孕婦與低風險孕婦髮生妊娠閤併貧血、妊娠期高血壓疾病、妊娠期糖尿病、胎盤異常、羊水過少、胎兒宮內窘迫、新生兒室息間比較差異有統計學意義（P＜0.01，P＜0.05）；D S篩查中風險孕婦與低風險孕婦髮生胎盤異常、新生兒室息間比較差異有統計學意義（P＜0.05）。結論：＜35歲孕婦孕中期血清學篩查D S風險值與不良妊娠結跼髮生的關繫密切，如能加彊對DS篩查高風險、中風險孕婦及其圍產兒的鑑測和管理，可降低不良妊娠結跼的髮生。
목적：탐토＜35세잉부잉중기혈청학사사당씨종합정（(Down syndrome，DS)）풍험치여불량임신결국발생적관계，평개D S사사풍험치대불량임신결국적예측개치。방법：선택2014년1월도2014년12월재아문산전사사문진진행잉중기혈청학사사DS고풍험、중풍험、저풍험예산기년령＜35주세단태임신잉부각562례，관찰삼조잉부발생임신합병빈혈、임신기고혈압질병、임신기당뇨병、태반이상、양수과소등내용；관찰삼조위산인발생조산인、태인궁내발육지완、태인궁내군박、신생인실식、위산인사망등내용。결과：DS사사고풍험잉부여중풍험잉부발생임신기고혈압질병、양수과소、태인궁내군박간비교차이유통계학의의（P＜0.05）；D S사사고풍험잉부여저풍험잉부발생임신합병빈혈、임신기고혈압질병、임신기당뇨병、태반이상、양수과소、태인궁내군박、신생인실식간비교차이유통계학의의（P＜0.01，P＜0.05）；D S사사중풍험잉부여저풍험잉부발생태반이상、신생인실식간비교차이유통계학의의（P＜0.05）。결론：＜35세잉부잉중기혈청학사사D S풍험치여불량임신결국발생적관계밀절，여능가강대DS사사고풍험、중풍험잉부급기위산인적감측화관리，가강저불량임신결국적발생。
Objective : To investigate the relationship between Down syndrome (DS) risk value and the occurrence of adverse pregnancy outcomes in the second trimester of pregnant women aged < 35 via serum screening and evaluate the predictive value of adverse pregnancy outcomes via DS screening risk value.Methods: Select separatively 562 cases of high-risk, medium-risk and low-risk second-trimester singleton pregnant women aged <35 via DS serum screening in our prenatal screening clinic from January 2014 to December 2014 and observe gestational anemia, gestational hypertension, gestational diabetes, placental abnormalities, oligohydramnios, etc. of the three groups of pregnant women and also observe perinatal preterm children, intrauterine growth retardation, fetal distress, neonatal asphyxia, perinatal death of the three groups.Results: Statistically significant (P<0.05) are the differences between high-risk pregnant women and medium-risk pregnant women with gestational hypertension, oligohydramnios and fetal distress via serum screening, the differences between high-risk pregnant women and low-risk pregnant women with gestational anemia, gestational hypertension, gestational diabetes, placental abnormalities, oligohydramnios, fetal distress and perinatal death via serum screening (P<0.01,P <0.05) and the differences between medium-risk pregnant women and low-risk pregnant women with placental abnormalities and perinatal death via serum screening (P<0.05).Conclusion: <35-year-old second-trimester pregnant women’s DS risk value via serum screening is closely related to the occurrence of adverse pregnancy outcomes.If we can strengthen the monitoring and management of DS serum screening of high-risk pregnant women, medium-risk pregnant women and perinatal children, the incidence of adverse pregnancy outcomes can be reduced.
