CAJ | 학술논문

多细胞生物基因组的特点是普遍表达不同类型的非编码RNA( ncRNAs)。长链ncRNAs ( LncRNAs)作为ncRNA中一种新的类型,包含着数千种不同的种类。 LncRNAs在分化和发育过程中起关键作用,并且在复杂生物体基因组内发现的LncRNAs数量不断增加,也暗示了其在多细胞生物进化过程中调控的重要性。研究表明,LncRNAs在剂量补偿、基因印迹、细胞分化及器官形成等方面发挥着重要功能,特别是在哺乳动物的发育过程中发挥着不可替代的作用。
다세포생물기인조적특점시보편표체불동류형적비편마RNA( ncRNAs)。장련ncRNAs ( LncRNAs)작위ncRNA중일충신적류형,포함착수천충불동적충류。 LncRNAs재분화화발육과정중기관건작용,병차재복잡생물체기인조내발현적LncRNAs수량불단증가,야암시료기재다세포생물진화과정중조공적중요성。연구표명,LncRNAs재제량보상、기인인적、세포분화급기관형성등방면발휘착중요공능,특별시재포유동물적발육과정중발휘착불가체대적작용。
Characteristics of genome of multicellular organisms is widely expressed various types of non-coding RNAs(ncRNAs). Long non-coding RNA(LncRNAs),as a new type of ncRNAs,contains thousands of different species. It plays a critical role in differentiation and development,and the number of LncRNAs discovered in the genome of complex organisms is keep increasing,which suggests the importance of its regu-lation in multicellular organisms during evolution. Researches have shown LncRNAs plays an important role in many processes,for example in the dosage compensation,gene imprinting,cell differentiation and organ for-mation,particularly in the development of the mammal.