中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
Chinese Journal of Experimental Surgery
2015年
9期
2270-2272
,共3页
Endoglin%非小细胞肺癌
Endoglin%非小細胞肺癌
Endoglin%비소세포폐암
Endoglin%Non-small cell lung carcinoma
目的 探讨Endoglin标记的微血管密度计数(MVD)、肽基脯氨酰顺反异构酶(Pin1)和微管不稳定蛋白(Stathmin)在非小细胞肺癌(NSCLC)组织中的表达及与NSCLC临床病理特征的关系.方法 利用免疫组织化学方法检测42例NSCLC组织和20例癌旁组织中Endoglin标记的MVD、Pin1和Stathmin的表达.结果 Endoglin标记的MVD在NSCLC癌组织中表达强度为41.26±2.32,明显高于在癌旁组织中表达强度(23.04±1.44),两者差异有统计学意义(P＜0.01),Endoglin标记的MVD表达强度与NSCLC的TNM分期、淋巴结转移明显相关(P＜0.05);Pin1在NSCLC组织中表达率明显高于癌旁组织(83.33％比25.00％,P＜0.05),Pin1表达水平与NSCLC的TNM分期、淋巴结转移明显相关(P＜0.05);Stathmin在NSCLC组织中表达率明显高于癌旁组织(64.29％比30.00％,P＜0.05),Stathmin表达水平与NSCLC的组织学分化程度、TNM分期、淋巴结转移明显相关(P＜0.05).结论 Endoglin、Pin1和Stathmin高表达与NSCLC的发生发展密切相关.
目的 探討Endoglin標記的微血管密度計數(MVD)、肽基脯氨酰順反異構酶(Pin1)和微管不穩定蛋白(Stathmin)在非小細胞肺癌(NSCLC)組織中的錶達及與NSCLC臨床病理特徵的關繫.方法 利用免疫組織化學方法檢測42例NSCLC組織和20例癌徬組織中Endoglin標記的MVD、Pin1和Stathmin的錶達.結果 Endoglin標記的MVD在NSCLC癌組織中錶達彊度為41.26±2.32,明顯高于在癌徬組織中錶達彊度(23.04±1.44),兩者差異有統計學意義(P＜0.01),Endoglin標記的MVD錶達彊度與NSCLC的TNM分期、淋巴結轉移明顯相關(P＜0.05);Pin1在NSCLC組織中錶達率明顯高于癌徬組織(83.33％比25.00％,P＜0.05),Pin1錶達水平與NSCLC的TNM分期、淋巴結轉移明顯相關(P＜0.05);Stathmin在NSCLC組織中錶達率明顯高于癌徬組織(64.29％比30.00％,P＜0.05),Stathmin錶達水平與NSCLC的組織學分化程度、TNM分期、淋巴結轉移明顯相關(P＜0.05).結論 Endoglin、Pin1和Stathmin高錶達與NSCLC的髮生髮展密切相關.
목적 탐토Endoglin표기적미혈관밀도계수(MVD)、태기포안선순반이구매(Pin1)화미관불은정단백(Stathmin)재비소세포폐암(NSCLC)조직중적표체급여NSCLC림상병리특정적관계.방법 이용면역조직화학방법검측42례NSCLC조직화20례암방조직중Endoglin표기적MVD、Pin1화Stathmin적표체.결과 Endoglin표기적MVD재NSCLC암조직중표체강도위41.26±2.32,명현고우재암방조직중표체강도(23.04±1.44),량자차이유통계학의의(P＜0.01),Endoglin표기적MVD표체강도여NSCLC적TNM분기、림파결전이명현상관(P＜0.05);Pin1재NSCLC조직중표체솔명현고우암방조직(83.33％비25.00％,P＜0.05),Pin1표체수평여NSCLC적TNM분기、림파결전이명현상관(P＜0.05);Stathmin재NSCLC조직중표체솔명현고우암방조직(64.29％비30.00％,P＜0.05),Stathmin표체수평여NSCLC적조직학분화정도、TNM분기、림파결전이명현상관(P＜0.05).결론 Endoglin、Pin1화Stathmin고표체여NSCLC적발생발전밀절상관.
Objective To investigate the expression of microvessel density (MVD) marked with endoglin,peptidy1 proly1 cis-trans isomerase (Pin1) and stathmin in non-small cell lung carcinoma (NSCLC) and to explore its relevance to the clinicopathologic features.Methods The expression of MVD marked with endoglin,Pin1 and stathmin was detected by immunohistochemistry in 42 cases of NSCLC tissues and 20 cases of non-cancerous adjacent lung tissues.Results The expression of MVD marked with endoglin was 41.26 ± 2.32 in NSCLC tissues,and 23.04 ± 1.44 in non-cancerous adjacent lung tissues (P ＜0.01).The expression of MVD marked with endoglin were related NSCLC to TNM stage and lymph node metastasis (P ＜ 0.05).The expression rate of Pin1 in NSCLC tissues was higher than that in non-cancerous adjacent lung tissues (83.33％ vs.25.00％,P ＜ 0.05).The expressions of Pin1 was related NSCLC to TNM stage and lymph node metastasis (P ＜ 0.05).The expression rate of stathmin in NSCLC tissues was higher than that in non-cancerous adjacent lung tissues (64.29％ vs.30.00％,P ＜ 0.05).The expressions of stathmin was related NSCLC to histologic grade,TNM stage and lymph node metastasis (P ＜0.05).Conclusion The overexpression of endoglin,Pin1 and stathmin may play important roles in the occurrence and development of NSCLC,and they can be used as reference index of the malignant degree and poor prognosis of NSCLC.
