医学综述
醫學綜述
의학종술
Medical Recapitulate
2015年
17期
3262-3263
,共2页
呼吸道疾病%阿奇霉素%低龄儿童%不良反应%预防措施
呼吸道疾病%阿奇黴素%低齡兒童%不良反應%預防措施
호흡도질병%아기매소%저령인동%불량반응%예방조시
Respiratory diseases%Azithromycin%Young children%Adverse reactions%Preventive meas-ures
目的：分析低龄儿童(6岁以下)呼吸道疾病应用阿奇霉素的不良反应事件并探讨合理的预防措施。方法选择2013年1~12月在十堰市东风汽车公司花果医院使用阿奇霉素治疗的低龄儿童作为研究对象。在2013年7月后实施综合性的预防措施。随机抽取2013年1~6月的300例病例资料作为对照组。另选2013年7~12月病例300例作为观察组。比较两组患儿各类不良反应发生率。结果预防措施实施后，观察组消化系统[21．0%(63/300)比28．7%(86/300)]、泌尿系统[5．3%(16/300)比10．0%(30/300)]、循环系统[3．7%(11/300)比7．7%(23/300)]、过敏性休克[2．0%(6/300)比5．0%(15/300)]不良反应发生率较对照组均明显降低(P<0．05)。观察组不良反应发生率与对照组比较明显降低(P<0．01)。结论通过采取预防措施可有效降低阿奇霉素所致不良反应的发生率。
目的：分析低齡兒童(6歲以下)呼吸道疾病應用阿奇黴素的不良反應事件併探討閤理的預防措施。方法選擇2013年1~12月在十堰市東風汽車公司花果醫院使用阿奇黴素治療的低齡兒童作為研究對象。在2013年7月後實施綜閤性的預防措施。隨機抽取2013年1~6月的300例病例資料作為對照組。另選2013年7~12月病例300例作為觀察組。比較兩組患兒各類不良反應髮生率。結果預防措施實施後，觀察組消化繫統[21．0%(63/300)比28．7%(86/300)]、泌尿繫統[5．3%(16/300)比10．0%(30/300)]、循環繫統[3．7%(11/300)比7．7%(23/300)]、過敏性休剋[2．0%(6/300)比5．0%(15/300)]不良反應髮生率較對照組均明顯降低(P<0．05)。觀察組不良反應髮生率與對照組比較明顯降低(P<0．01)。結論通過採取預防措施可有效降低阿奇黴素所緻不良反應的髮生率。
목적：분석저령인동(6세이하)호흡도질병응용아기매소적불량반응사건병탐토합리적예방조시。방법선택2013년1~12월재십언시동풍기차공사화과의원사용아기매소치료적저령인동작위연구대상。재2013년7월후실시종합성적예방조시。수궤추취2013년1~6월적300례병례자료작위대조조。령선2013년7~12월병례300례작위관찰조。비교량조환인각류불량반응발생솔。결과예방조시실시후，관찰조소화계통[21．0%(63/300)비28．7%(86/300)]、비뇨계통[5．3%(16/300)비10．0%(30/300)]、순배계통[3．7%(11/300)비7．7%(23/300)]、과민성휴극[2．0%(6/300)비5．0%(15/300)]불량반응발생솔교대조조균명현강저(P<0．05)。관찰조불량반응발생솔여대조조비교명현강저(P<0．01)。결론통과채취예방조시가유효강저아기매소소치불량반응적발생솔。
Objective To analyze the adverse reaction of young children with respiratory disease caused by azithromycin,and explore the reasonable precautions. Methods Young children treated by azithromycin in Shiyan Huaguo Hospital of Dongfeng Motor Corporation from Jan. to Dec. 2013 were included in the study. The general precautions was implemented after July 2013,300 cases from Jan. to Jun. 2013 were included as control group,300 cases from Jul. to Dec. 2013 were included as the observation group. The type of adverse reaction and the incidence of adverse reactions were selected as evaluating indicators. Results After the implementation of preventive measures,the incidence of adverse reactions of the digestive system [21. 0%(63/300) vs 28. 7% (86/300)],the urinary system [5. 3% (16/300) vs 10. 0% (30/300)],the circu-latory system [3. 7% (11/300) vs 7. 7% (23/300)] were significantly lower than before the implementa-tion of preventive measures(P<0. 05). After the implementation of preventive measures,the incidence of adverse reactions in the observation group was significantly lower than the control group (P <0. 01). Conclusion The comprehensive preventive measures can effectively reduce the incidence of azithromycin-induced adverse reactions.
