CAJ | 학술논문

目的：研究肺炎支原体肺炎（MPP）患儿不同时期血清白细胞介素‐37（IL‐37）及白细胞介素‐18（IL‐18）的水平变化，并探讨其在MPP发生、发展中的作用及意义。方法：（1）采用双抗体夹心酶联免疫法（ELISA）测定40例MPP患儿（M PP组）急性期和恢复期血清IL‐37及IL‐18水平，与40例健康体检儿童（对照组）进行比较；（2）比较M PP重症与轻症患儿血清IL‐37及IL‐18水平变化；（3）分析M PP组急性期IL‐37与IL‐18的相关性。结果：（1） M PP组急性期血清IL‐37及IL‐18水平均显著高于恢复期及对照组，差异均有统计学意义（P＜0．01）；（2）MPP组恢复期血清IL‐37及IL‐18水平高于对照组，差异均有统计学意义（P＜0．01）；（3） MPP组重症与轻症比较，重症患儿血清IL‐37、IL‐18水平呈在急性期和恢复期均高于轻症患儿，差异均有统计学意义（ P＜0．05）；（4）M PP急性期血清IL‐37及IL‐18水平呈显著正相关（P＜0．01）。结论：（1）IL‐37及IL‐18可能参与了MPP的发生、发展；（2）IL‐37及IL‐18二者互为影响，在一定程度上有助于临床监测病情。
목적：연구폐염지원체폐염（MPP）환인불동시기혈청백세포개소‐37（IL‐37）급백세포개소‐18（IL‐18）적수평변화，병탐토기재MPP발생、발전중적작용급의의。방법：（1）채용쌍항체협심매련면역법（ELISA）측정40례MPP환인（M PP조）급성기화회복기혈청IL‐37급IL‐18수평，여40례건강체검인동（대조조）진행비교；（2）비교M PP중증여경증환인혈청IL‐37급IL‐18수평변화；（3）분석M PP조급성기IL‐37여IL‐18적상관성。결과：（1） M PP조급성기혈청IL‐37급IL‐18수평균현저고우회복기급대조조，차이균유통계학의의（P＜0．01）；（2）MPP조회복기혈청IL‐37급IL‐18수평고우대조조，차이균유통계학의의（P＜0．01）；（3） MPP조중증여경증비교，중증환인혈청IL‐37、IL‐18수평정재급성기화회복기균고우경증환인，차이균유통계학의의（ P＜0．05）；（4）M PP급성기혈청IL‐37급IL‐18수평정현저정상관（P＜0．01）。결론：（1）IL‐37급IL‐18가능삼여료MPP적발생、발전；（2）IL‐37급IL‐18이자호위영향，재일정정도상유조우림상감측병정。
Objective :Study of children with mycoplasma pneumoniae pneumonia (MPP) at different times of serum interleukin 37 (IL‐37) and interleukin 18 (IL‐18) levels of change ,and to explore its role in the occurrence and devel‐opment of MPP and significance .Methods :(1) With double antibody sandwich enzyme‐linked immunoassay (ELISA) determination of 40 cases of children with MPP acute phase and convalescence ,serum levels of IL‐37 and IL‐18 ,and compared with 40 cases of healthy check‐up children (control group) were compared ;(2)MPP severe and mild serum IL‐37 and IL‐18 level changes ;(3)compare the MPP acute IL‐37 and the correlation of IL‐18 .Results:(1)MPP children with acute phase serum IL‐37 and IL‐18 levels were significantly higher than that of recovery and healthy controls chil‐dren ,differences were statistically significant (P<0 .01);(2)the recovery of serum IL‐37 children with MPP and level of IL‐18 children is higher than the healthy controls ,differences were statistically significant (P<0 .01);(3)the MPP children with severe compared with mild ,severe patients serum IL‐37 ,IL‐18 level were higher than in children with mild acute phase and convalescence and the differences were statistically significant (P<0 .05);(4)MPP acute phase serum IL‐37 and IL‐18 were significantly positive correlation (P< 0 .01) .Conclusion:(1)IL‐37 and IL‐18 maybe have involved in the occurrence and development of mycoplasma pneumoniae pneumonia ;(2)IL‐37 and IL‐18 both influence each other .in a certain extent ,It is helpful to the clinical monitoring condition .