CAJ | 학술논문

目的：观察阳参益肾胶囊对系统性红斑狼疮患者激素减量维持阶段补体水平的稳定作用和免疫调节作用。方法：选取经治疗后补体水平正常，而在随诊时（激素减量维持阶段）补体水平低于正常值的系统性红斑狼疮患者32例，随机分为治疗组和对照组，每组16例。对照组继续予激素和羟氯喹等药物常规治疗，治疗组在对照组治疗基础上加用阳参益肾胶囊。两组疗程均为4周，分别在治疗前后测定患者补体（C3、C4）、免疫球蛋白（IgG、IgA、IgM）、C-反应蛋白（CRP）、红细胞沉降率（ESR）、血尿常规、24 h尿蛋白定量等水平以及SLE疾病活动指数评分（SLEDAI）。结果：治疗后，治疗组补体C3、C4水平均有不同程度的升高，与对照组比较，差异有统计学意义（P =0.001或P =0.000）；治疗组补体C3、C4水平正常率较对照组高，差异有统计学意义（P =0.029或P =0.023）。治疗组24h尿蛋白定量和SLEDAI评分治疗前后比较，差异有统计学意义（P =0.014或P =0.001）。结论：阳参益肾胶囊对系统性红斑狼疮激素减量维持阶段的补体水平可能具有良好的稳定作用。
목적：관찰양삼익신효낭대계통성홍반랑창환자격소감량유지계단보체수평적은정작용화면역조절작용。방법：선취경치료후보체수평정상，이재수진시（격소감량유지계단）보체수평저우정상치적계통성홍반랑창환자32례，수궤분위치료조화대조조，매조16례。대조조계속여격소화간록규등약물상규치료，치료조재대조조치료기출상가용양삼익신효낭。량조료정균위4주，분별재치료전후측정환자보체（C3、C4）、면역구단백（IgG、IgA、IgM）、C-반응단백（CRP）、홍세포침강솔（ESR）、혈뇨상규、24 h뇨단백정량등수평이급SLE질병활동지수평분（SLEDAI）。결과：치료후，치료조보체C3、C4수평균유불동정도적승고，여대조조비교，차이유통계학의의（P =0.001혹P =0.000）；치료조보체C3、C4수평정상솔교대조조고，차이유통계학의의（P =0.029혹P =0.023）。치료조24h뇨단백정량화SLEDAI평분치료전후비교，차이유통계학의의（P =0.014혹P =0.001）。결론：양삼익신효낭대계통성홍반랑창격소감량유지계단적보체수평가능구유량호적은정작용。
Objective:To observe the stabilization role of Yangshen Yishen Capsule(阳参℃肾胶囊) for the level of complement at the maintenance phase of systemic lupus erythematosus by reducing hormone. Methods:32 cases of systemic lupus erythematosus,with normal complement level after treatment and lower complement level than the normal value during follow-up,were selected and divided into a treatment group and a control group,16 patients in each group.The control group was continuously and routinely treated with hormone and hydroxychloroquine,while the treatment group was given Yangshen Yishen Capsule based on the treatment for the control group.Compliment C3 and C4,immunoglobulin IgG,IgA and IgM,CRP,ESR,blood and urine routine, 24 h urinary protein quantitation and SLEDAI(Systemic Lupus Erythematosus Disease Activity Index) were measured before and after treatment.Results:After treatment,the levels of them in the treatment group were higher to a certain degree.Compared with those in the control group,the difference was statistically signiifcant (P = 0.001 orP = 0.000);the normal rates of the levels of C3 and C4 in the treatment group were higher than those in the control group(P = 0.029 orP = 0.023).Before and after treatment,the difference of 24 h urinary protein quantitation and SLEDAI score in the treatment group was statistically signiifcant(P = 0.014 orP = 0.001). Conclusion:Yangshen Yishen Capsule has a good stabilization role for the level of complement at the maintenance phase of systemic lupus erythematosus by reducing hormone.