CAJ | 학술논문

目的通过犬后肢爆炸伤合并海水浸泡伤模型,探讨大网膜游离移植在肢体爆炸伤合并海水浸泡后的应用价值.方法 32只杂种犬按体质量作为配对因素,用区组随机排列的方式分为大网膜游离移植组(大网膜组)和腹直肌肌皮瓣游离移植组(肌皮瓣组),每组16只.每只犬的左后肢炸伤后,立即浸入含副溶血弧菌(1.0×106 cfu/ml)的海水中1h.3d后分别行大网膜游离移植或腹直肌肌皮瓣游离移植修复创面.观察2组术后全身反应、局部感染情况、骨折愈合情况和病理学检查结果等,比较2组的修复能力.结果大网膜组14只、肌皮瓣组15只组织瓣存活,2组存活率差异无统计学意义(P＞0.05);全身反应的严重程度、局部感染发生率和局部中性分叶核浸润情况等方面,大网膜组均低于肌皮瓣组,说明大网膜游离移植后局部抗感染能力较强;大网膜组4个月时骨折愈合率为73.3％,明显高于肌皮瓣组的42.9％.结论在特定的环境下应用大网膜游离移植修复肢体爆炸伤合并海水浸泡伤来说,可以获得较好的效果.
목적 통과견후지폭작상합병해수침포상모형,탐토대망막유리이식재지체폭작상합병해수침포후적응용개치.방법 32지잡충견안체질량작위배대인소,용구조수궤배렬적방식분위대망막유리이식조(대망막조)화복직기기피판유리이식조(기피판조),매조16지.매지견적좌후지작상후,립즉침입함부용혈호균(1.0×106 cfu/ml)적해수중1h.3d후분별행대망막유리이식혹복직기기피판유리이식수복창면.관찰2조술후전신반응、국부감염정황、골절유합정황화병이학검사결과등,비교2조적수복능력.결과 대망막조14지、기피판조15지조직판존활,2조존활솔차이무통계학의의(P＞0.05);전신반응적엄중정도、국부감염발생솔화국부중성분협핵침윤정황등방면,대망막조균저우기피판조,설명대망막유리이식후국부항감염능력교강;대망막조4개월시골절유합솔위73.3％,명현고우기피판조적42.9％.결론 재특정적배경하응용대망막유리이식수복지체폭작상합병해수침포상래설,가이획득교호적효과.
Objective To investigate the application of omentum free grafting in the treatment of explosive wounds with seawater immersion in the dog limb,through an animal model of explosive wounds coupled with seawater immersion.Methods In accordance with their body mass,32 mongrel dogs were divided into 2 groups,the omentum free grafting group (or simply the omentum group) and the abdominal muscle free grafting group (or simply the muscle group),each consisting of 16 animals.The left hinder limbs of the dogs were immersed in the artificial seawater with parahaemolyticus (1.0 × 106 cfu/ml) for one hour following blasting.Three days later,omentum free grafting and abdominal muscle free grafting were performed to repair the wound surface.Then,systemic reaction,local infection,bone fracture healing and pathological detection were closely observed,and the repair capacity was compared between the 2 groups.Results The tissue flaps in the 14 animals of the omentum group and 15 animals of the muscle group survived,however no statistical significance could be noted,when comparisons were made in the survival rates of the two groups (P ＞ 0.05).From the seriousness of systemic reaction,rate of local infection and local lobulated infiltration,the levels of the omentum group were all lower than those of the muscle group,indicating that the capacity of local anti-infection of the omentum group was greater following omentum free grafting.The healing rate of bone fracture for the omentum group at month 4 was 73.3％,which was significantly higher than that of the muscle flap group (42.9％).Conclusions In the treatment of explosive wounds coupled with seawater immersion,the application of omentum free grafting could achieve satisfactory results,under certain specific conditions.