CAJ | 학술논문

1-磷酸鞘胺醇(S1P)是神经酰胺代谢产生的一种生物活性脂质.它不仅是细胞外介质,也是细胞内第二信使,参与细胞的增殖、分化等生理过程.S1P与不同的受体结合产生的作用各异.研究表明其可以通过不同的途径参与胰岛素信号的调节,对胰岛素信号产生不同的影响,与肝脏、骨骼肌、胰岛等组织胰岛素抵抗的发生密切相关.
1-린산초알순(S1P)시신경선알대사산생적일충생물활성지질.타불부시세포외개질,야시세포내제이신사,삼여세포적증식、분화등생리과정.S1P여불동적수체결합산생적작용각이.연구표명기가이통과불동적도경삼여이도소신호적조절,대이도소신호산생불동적영향,여간장、골격기、이도등조직이도소저항적발생밀절상관.
Sphingosine-1-phosphate(S1P) is a bioactive lipid metabolite of ceramide.It is not only the extracellular mediator,but also the intracellular second messenger involved in cell proliferation,differentiation,and other physiological processes.S1P has various effects when combining to different receptors.Studies have showed that it plays a role in insulin signaling regulation by diverse ways resulting in different influence.It is closely correlated with insulin resistance in liver,skeletal muscle,islet and so on.