国际内分泌代谢杂志
國際內分泌代謝雜誌
국제내분비대사잡지
International Journal of Endocrinology and Metabolism
2015年
5期
354-356
,共3页
糖尿病肾病%血管内皮细胞生长因子%一氧化氮%一氧化氮合酶%氧化应激
糖尿病腎病%血管內皮細胞生長因子%一氧化氮%一氧化氮閤酶%氧化應激
당뇨병신병%혈관내피세포생장인자%일양화담%일양화담합매%양화응격
Diabetic nephropathy%Vascular endothelial growth factor%Nitric oxide%Nitric oxide synthase%Oxidative stress
血管内皮生长因子(VEGF)-一氧化氮(NO)耦联被称为VEGF-NO轴,其对维持肾小球血管内皮细胞功能起重要作用,其解耦联可能参与糖尿病肾病的发生、发展.内皮型一氧化氮合酶(eNOS)活性降低可能是糖尿病肾脏VEGF-NO轴解耦联的关键环节.肥胖、高脂血症以及氧化应激是导致糖尿病肾脏VEGF-NO轴解耦联的重要原因.脂联素、血红素加氧酶-1明显改善糖尿病大鼠肾小球血管内皮细胞的功能、降低白蛋白尿,其机制可能是通过抗氧化应激作用改善VEGF-NO轴的功能.
血管內皮生長因子(VEGF)-一氧化氮(NO)耦聯被稱為VEGF-NO軸,其對維持腎小毬血管內皮細胞功能起重要作用,其解耦聯可能參與糖尿病腎病的髮生、髮展.內皮型一氧化氮閤酶(eNOS)活性降低可能是糖尿病腎髒VEGF-NO軸解耦聯的關鍵環節.肥胖、高脂血癥以及氧化應激是導緻糖尿病腎髒VEGF-NO軸解耦聯的重要原因.脂聯素、血紅素加氧酶-1明顯改善糖尿病大鼠腎小毬血管內皮細胞的功能、降低白蛋白尿,其機製可能是通過抗氧化應激作用改善VEGF-NO軸的功能.
혈관내피생장인자(VEGF)-일양화담(NO)우련피칭위VEGF-NO축,기대유지신소구혈관내피세포공능기중요작용,기해우련가능삼여당뇨병신병적발생、발전.내피형일양화담합매(eNOS)활성강저가능시당뇨병신장VEGF-NO축해우련적관건배절.비반、고지혈증이급양화응격시도치당뇨병신장VEGF-NO축해우련적중요원인.지련소、혈홍소가양매-1명현개선당뇨병대서신소구혈관내피세포적공능、강저백단백뇨,기궤제가능시통과항양화응격작용개선VEGF-NO축적공능.
The coupling of vascular endothelial growth factor (VEGF) with nitric oxide (NO),known as the VEGF-NO axis,plays a critical role in maintaining normal glomerular endothelial cell function,its uncoupling involves in the occurrence and development of diabetic nephropathy.Reduction of endothelial nitric oxide synthase (eNOS) activity is likely to be the key mechanism of VEGF-NO axial decoupling in diabetic kidney.Obesity,hyperlipidemia,and oxidative stress may be main reasons of VEGF-NO axis uncoupling in diabetes kidney.Adiponectin,heme oxygenase-1 could obviously improve glomerular endothelial cell function of diabetic rat,reduce proteinuria via resisting oxidative stress to improve the function of the VEGF-NO axis.