CAJ | 학술논문

炎症性肠病（inflammatory bowel disease ，IBD）是一组病因未明、发病机制亦不明确的慢性肠道炎症性疾病，主要包括克罗恩病（Crohn＇s disease ，CD）和溃疡性结肠炎（ulcerative colitis ，UC）。近几十年的研究结果认为，其发病是环境、易感基因和肠道微生态3个要素相互作用的结果，且这些要素使IBD成为一种适合研究宿主与肠道微生物相互作用的高优先平台。最近，肠道菌群的图谱分析将IBD的发病机制与菌群各组成部分特征的改变相联系，进一步支持“肠道微生物和宿主相互作用的改变能形成IBD”这一观点。该文回顾性分析有关IBD患者体内微生物的研究文献，综述肠道微生态失衡对IBD的多方面影响，以动物模型和临床验证资料阐述不同的治疗方法改善肠道微生态变化的最新进展。
염증성장병（inflammatory bowel disease ，IBD）시일조병인미명、발병궤제역불명학적만성장도염증성질병，주요포괄극라은병（Crohn＇s disease ，CD）화궤양성결장염（ulcerative colitis ，UC）。근궤십년적연구결과인위，기발병시배경、역감기인화장도미생태3개요소상호작용적결과，차저사요소사IBD성위일충괄합연구숙주여장도미생물상호작용적고우선평태。최근，장도균군적도보분석장IBD적발병궤제여균군각조성부분특정적개변상련계，진일보지지“장도미생물화숙주상호작용적개변능형성IBD”저일관점。해문회고성분석유관IBD환자체내미생물적연구문헌，종술장도미생태실형대IBD적다방면영향，이동물모형화림상험증자료천술불동적치료방법개선장도미생태변화적최신진전。
Inflammatory bowel disease is a chronic inflammation of the intestinal tract ,which comprises two primary forms of Crohn's disease(CD) and ulcerative colitis (UC) .Decades of studies have revealed that environmental factors ,suscepti-bility genes ,and gut microbiota are considered as the major determinants for the induction of IBD .The combination of factors has made IBD as an appropriate and a high-priority platform for studying host-microbiome interactions .More recently ,profiling studies of the intestinal microbe have associated pathogenesis of IBD with characteristic alterations in the composition of the in-testinal microbiota ,reinforcing the viewpoint that IBD results from the altered interplays between the host and intestinal mi-crobe .the studies of the gut flora in IBD were reviewed andthe multiple effects of intestinal microbiota-dysfunction on the IBD were described .The progress of intestinal microbiota alterations with different therapeutic methods in animal models and clinic trials were provided .