CAJ | 학술논문

目的探讨血清25羟维生素D[25(OH)D]及vaspin与妊娠糖尿病的关系.方法选取妊娠24 ～ 28周的女性244名,根据口服葡萄糖耐量试验(OGTT)的结果,分为正常妊娠组(n=102)、妊娠糖尿病组(n=142),同时选择正常非妊娠女性90名作为对照组.分别检测各组空腹血糖、甘油三酯、总胆固醇、空腹胰岛素(FINS)、血清25(OH)D含量和vaspin水平,并计算稳态模型评估-胰岛素抵抗指数(HOMA-IR).分析25(OH)D与vaspin、空腹胰岛素及HOMA-IR的相关性.结果妊娠糖尿病组空腹血糖水平、HOMA-IR较正常妊娠组及对照组升高(F=39.402,12.147,P均＜0.05);妊娠糖尿病组及正常妊娠组甘油三酯、总胆固醇及FINS水平较对照组升高(F=79.915,56.695,9.985,P均＜0.05).妊娠糖尿病组25(OH)D水平较正常妊娠组及对照组降低(F=50.875,P＜0.05),而vaspin水平较正常妊娠组及对照组升高(F=30.678,P＜0.05);且25(OH)D水平与FINS(r=-0.913,P=0.012)、HOMA-IR(r=-0.181,P=0.019)呈负相关,与vaspin(r=-0.084,P=0.279)水平无关,vaspin水平与空腹血糖(r=0.208,P=0.007)、FINS(r=0.352,P=0.000)、HOMA-IR(r=0.366,P=0.000)呈正相关.Logistic回归分析显示25(OH)D缺乏是妊娠糖尿病的独立危险因素.结论妊娠糖尿病患者血清25 (OH)D水平降低,vaspin水平升高.血清25(OH)D可能影响胰岛β细胞功能,参与妊娠糖尿病的发展.
목적 탐토혈청25간유생소D[25(OH)D]급vaspin여임신당뇨병적관계.방법 선취임신24 ～ 28주적녀성244명,근거구복포도당내량시험(OGTT)적결과,분위정상임신조(n=102)、임신당뇨병조(n=142),동시선택정상비임신녀성90명작위대조조.분별검측각조공복혈당、감유삼지、총담고순、공복이도소(FINS)、혈청25(OH)D함량화vaspin수평,병계산은태모형평고-이도소저항지수(HOMA-IR).분석25(OH)D여vaspin、공복이도소급HOMA-IR적상관성.결과 임신당뇨병조공복혈당수평、HOMA-IR교정상임신조급대조조승고(F=39.402,12.147,P균＜0.05);임신당뇨병조급정상임신조감유삼지、총담고순급FINS수평교대조조승고(F=79.915,56.695,9.985,P균＜0.05).임신당뇨병조25(OH)D수평교정상임신조급대조조강저(F=50.875,P＜0.05),이vaspin수평교정상임신조급대조조승고(F=30.678,P＜0.05);차25(OH)D수평여FINS(r=-0.913,P=0.012)、HOMA-IR(r=-0.181,P=0.019)정부상관,여vaspin(r=-0.084,P=0.279)수평무관,vaspin수평여공복혈당(r=0.208,P=0.007)、FINS(r=0.352,P=0.000)、HOMA-IR(r=0.366,P=0.000)정정상관.Logistic회귀분석현시25(OH)D결핍시임신당뇨병적독립위험인소.결론 임신당뇨병환자혈청25 (OH)D수평강저,vaspin수평승고.혈청25(OH)D가능영향이도β세포공능,삼여임신당뇨병적발전.
Objective To investigate the relationship between serum 25-hydroxyvitamin D[25(OH) D],vaspin and gestational diabetes mellitus (GDM).Methods A total of 244 pregnant women at 24-28 weeks of gestation were divided into normal pregnant group (n =102) and GDM group (n =142) according to the results of oral glucose tolerance test (OGTT),and 90 normal non-pregnant women were served as control.Fasting plasma glucose,triglycerides,cholesterol,fasting insulin,25 (OH)D and vaspin levels were measured.The homeostasis model assessment-insulin resistance (HOMA-IR) were calculated.The relationship between 25 (OH) D and vaspin,FINS,HOMA-IR were analyzed.Results The levels of fasting plasma glucose and HOMA-IR in GDM group were higher than those in normal pregnant group and control group(F =39.402,2.147,all P ＜ 0.05).Triglycerides,cholesterol and fasting insulin in GDM group and normal pregnant group were higher than those in control group(F =79.915,56.695,9.985,all P ＜ 0.05).The level of 25 (OH)D in GDM group was lower than that in normal pregnant group and control group(F =50.875,P ＜0.05).The level of vaspin in GDM group was higher than that in normal pregnant group and control group(F =30.678,P ＜ 0.05).Serum 25 (OH) D level was negatively correlated with FINS (r =-0.913,P=0.012) and HOMA-IR(r =-0.181,P =0.019),and had no correlation with the level of vaspin (r =-0.084,P =0.279).Serum vaspin level was positively correlated with fasting plasma glucose (r =0.208,P =0.007),FINS(r =0.352,P =0.000) and HOMA-IR(r=0.366,P =0.000).Logistic regression analysis showed that lack of 25 (OH) D was an independent risk factor for GDM.Conclusions Serum 25 (OH) D decreases while serum vaspin level increases in patients with GDM.Serum 25 (OH) D may have impacts on the function of islet β cell,and then contributes to the development of GDM.