CAJ | 학술논문

目的介绍一种新型复合纳米凝胶负载入胎盘素提取物过程.方法取10 mg异亮氨酸-赖氨酸-缬氨酸-丙氨酸-缬氨酸(IKVAV)、自组装多肽分子(RAD16)、FGL多肽两亲性分子(FGL-PA)、精氨酸、甘氨酸和天冬氨酸合成多肽(RGD)联合制作理想纳米凝胶载体,纳米纤维凝胶稀释O、50、100倍后检测实验过程.结果纳米纤维凝胶的最佳配比:IKVAV∶ RGD∶ FGL-PA=1∶1∶1.人胎盘提取液纳米纤维凝胶的平均粒径为212.8 nm,缓释时间达4d以上.包裹人胎盘提取液纳米纤维中人胎盘提取液和原料药结构保持基本完整.结论这种新型纳米复合材料极可能为人胎盘素提取物提供理想的药物运载系统.
목적 개소일충신형복합납미응효부재입태반소제취물과정.방법 취10 mg이량안산-뢰안산-힐안산-병안산-힐안산(IKVAV)、자조장다태분자(RAD16)、FGL다태량친성분자(FGL-PA)、정안산、감안산화천동안산합성다태(RGD)연합제작이상납미응효재체,납미섬유응효희석O、50、100배후검측실험과정.결과 납미섬유응효적최가배비:IKVAV∶ RGD∶ FGL-PA=1∶1∶1.인태반제취액납미섬유응효적평균립경위212.8 nm,완석시간체4d이상.포과인태반제취액납미섬유중인태반제취액화원료약결구보지기본완정.결론저충신형납미복합재료겁가능위인태반소제취물제공이상적약물운재계통.
Objective To describe a novel nanocomposite gel fiber encapsulated human placental extract through layer-by-layer self-assembly.Methods The 10 mg of isoleucine-lysine-valine-alanine-valine(IKVAV),Arg-Gly-Asp (RGD) and FGL peptide-amphiphile (FGL-PA) were screened and combined to produce an optimal vehicle nanofiber gel through layer-by-layer assembly.We detected its morphology,particle size,drug loading efficacy,the encapsulation rate,release efficiency and the structure validation after it was diluted 0,50,100 times.Results The optimal proportion and concentration of nanometer fiber gel:IKVAV∶ RGD∶ FGL-PA =1 ∶ 1 ∶ 1,and 0.6 g/L by observing the liquidity,diffusion time and viscosity.The nanometer fiber gel had slow-releasing profile,its average particle size was 212.8 nm,and the slow release time was more than 4 days.The preliminary results confirmed that the structure of human placenta extract (HPE) encapsulated nanofiber gel was unvaried compared with the HPE structure.Conclusion This kind of novel composite nanocapsules may offer a promising delivery system for human placenta extract.