中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
Chinese Journal of Experimental Surgery
2015年
9期
2110-2112
,共3页
卢志刚%吕晓强%刘芸%黄家彬%孙圣刚
盧誌剛%呂曉彊%劉蕓%黃傢彬%孫聖剛
로지강%려효강%류예%황가빈%손골강
急性脑梗死%信号传导及转录激活子-4,6%脑梗死体积%神经功能缺损
急性腦梗死%信號傳導及轉錄激活子-4,6%腦梗死體積%神經功能缺損
급성뇌경사%신호전도급전록격활자-4,6%뇌경사체적%신경공능결손
Acute cerebral infarction%Signal transducer and activator of transcription-4,6%Infarction volume%Neurologic impairment
目的 探讨急性脑梗死(ACI)患者信号传导及转录激活子(STAT)-4、STAT-6水平与神经功能缺损以及脑梗死体积的相关性.方法 选择ACI患者122例为观察对象,采用酶联免疫法(ELISA)和免疫透射比浊法测定STAT-4、STAT-6和超敏C反应蛋白(hs-CRP)水平,与同期健康体检者74例对照比较.按照多田公司计算ACI患者脑梗死体积,分为大、中、小梗死组,根据神经功能缺损程度评分标准分为轻、中、重度损伤组,比较不同梗死体积与损伤程度时STAT-4、STAT-6和Hs-CRP水平的变化,并进行STAT-4、STAT-6与Hs-CRP之间的直线相关分析.结果 ACI患者血清STAT-4和hs-CRP水平明显高于对照组[(225.82±113.39)、(16.86±4.17) ng/L比(107.72±75.18)、(6.27±1.15) ng/L],STAT-6明显低于对照组[(305.89±117.26)ng/L比(421.65±107.76) ng/L],差异有统计学意义(P＜0.05).脑梗死体积越大,神经功能缺损程度越重,ACI患者血清中STAT-4和Hs-CRP水平越高,而STAT-6越低.血清STAT-4与hs-CRP水平正相关,而STAT-6为负相关(P＜0.05).结论 ACI患者STAT-4、STAT-6和hs-CRPP水平与脑梗死体积大小以及神经功能缺损程度明显相关,可提示ACI患者病情的发生发展以及严重程度.
目的 探討急性腦梗死(ACI)患者信號傳導及轉錄激活子(STAT)-4、STAT-6水平與神經功能缺損以及腦梗死體積的相關性.方法 選擇ACI患者122例為觀察對象,採用酶聯免疫法(ELISA)和免疫透射比濁法測定STAT-4、STAT-6和超敏C反應蛋白(hs-CRP)水平,與同期健康體檢者74例對照比較.按照多田公司計算ACI患者腦梗死體積,分為大、中、小梗死組,根據神經功能缺損程度評分標準分為輕、中、重度損傷組,比較不同梗死體積與損傷程度時STAT-4、STAT-6和Hs-CRP水平的變化,併進行STAT-4、STAT-6與Hs-CRP之間的直線相關分析.結果 ACI患者血清STAT-4和hs-CRP水平明顯高于對照組[(225.82±113.39)、(16.86±4.17) ng/L比(107.72±75.18)、(6.27±1.15) ng/L],STAT-6明顯低于對照組[(305.89±117.26)ng/L比(421.65±107.76) ng/L],差異有統計學意義(P＜0.05).腦梗死體積越大,神經功能缺損程度越重,ACI患者血清中STAT-4和Hs-CRP水平越高,而STAT-6越低.血清STAT-4與hs-CRP水平正相關,而STAT-6為負相關(P＜0.05).結論 ACI患者STAT-4、STAT-6和hs-CRPP水平與腦梗死體積大小以及神經功能缺損程度明顯相關,可提示ACI患者病情的髮生髮展以及嚴重程度.
목적 탐토급성뇌경사(ACI)환자신호전도급전록격활자(STAT)-4、STAT-6수평여신경공능결손이급뇌경사체적적상관성.방법 선택ACI환자122례위관찰대상,채용매련면역법(ELISA)화면역투사비탁법측정STAT-4、STAT-6화초민C반응단백(hs-CRP)수평,여동기건강체검자74례대조비교.안조다전공사계산ACI환자뇌경사체적,분위대、중、소경사조,근거신경공능결손정도평분표준분위경、중、중도손상조,비교불동경사체적여손상정도시STAT-4、STAT-6화Hs-CRP수평적변화,병진행STAT-4、STAT-6여Hs-CRP지간적직선상관분석.결과 ACI환자혈청STAT-4화hs-CRP수평명현고우대조조[(225.82±113.39)、(16.86±4.17) ng/L비(107.72±75.18)、(6.27±1.15) ng/L],STAT-6명현저우대조조[(305.89±117.26)ng/L비(421.65±107.76) ng/L],차이유통계학의의(P＜0.05).뇌경사체적월대,신경공능결손정도월중,ACI환자혈청중STAT-4화Hs-CRP수평월고,이STAT-6월저.혈청STAT-4여hs-CRP수평정상관,이STAT-6위부상관(P＜0.05).결론 ACI환자STAT-4、STAT-6화hs-CRPP수평여뇌경사체적대소이급신경공능결손정도명현상관,가제시ACI환자병정적발생발전이급엄중정도.
Objective To investigate the correlation between serum signal transducer and activator of transcription (STAT)-4,6,neurologic impairment and cerebral infarction volume in patients of acute cerebral infarction (ACI).Methods 122 patients with ACI and 74 synchronously examined healthy people(controls) were collected.The surum levels of STAT-4,6 and Hs-CRP were detected by eyzyme-linked immunosorbent assay (ELISA) and immunity transmission turbidity in all the subjected.The patients of cerebral infarction volume with ACI was calculated by pullicino formula,which were divided into small,middle and large infarction group.Based on the neurological functional deficit scale from standareds of CSS in 1995,the patients were divided into mild,moderate,severe impairment.Changes of the level of STAT-4,6 and Hs-CRP were compared in ACI patients with different cerebral infarction volume and different impairment degree.Linear correlation and regression analysis were performed to STAT-4,6 and Hs-CRP.Results The levels of serum STAT-4 and Hs-CRP were higher in ACI group than those in the control group [(225.82 ± 113.39),(16.86 ±4.17) ng/L vs.(107.72 ± 75.18),(6.27 ± 1.15) ng/L],however STAT-6 lower than those in the control group [(305.89 ± 117.26) ng/L vs.(421.65 ± 107.76) ng/L],and the differences was statically significant(P ＜ 0.05).The larger the infarction volume and the severer the neurologic impairment degree was in the patients with ACI,the higher the levels of serum STAT-4 and Hs-CRP,however the lower the levels of STAT-6.Linear regression analysis results showed that the level of STAT-4 was significantly positively correlated with the level of Hs-CRP,STAT-6 negative correlation (P ＜ 0.05).Conclusion There is a significant correlation between serm STAT-4,6 levels and infarct volume,neurologic impairment in ACI patients,which can provide some indicative effect for the occurrence and development and neurologic impairment degree of ischemic cerebrovascular diseases.
