CAJ | 학술논문

目的：探讨血清CEA、CA199在晚期结直肠癌中的分布及与临床特征的关系。方法将275例CRC患者分别按性别、年龄、肝转移、腹水、肠瘤直径、肠瘤位置、血便、乙肝进行分组，总结分析患者血清CEA、CA199的浓度均值、阳性率及与临床特征的关系。结果伴肝转移，肿瘤位于结肠，有血便，有腹水的CRC患者中血清CEA、CA199的浓度均值均明显升高，差异有统计学意义（ P＜0．05）。而血清CEA、CA199的水平与性别、年龄、肠瘤直径、乙肝无明显相关性（ P＞0．05）。结论血清CEA、CA199可作为早期诊断结直肠癌肝转移的一种有效方法，广泛的用于临床。
목적：탐토혈청CEA、CA199재만기결직장암중적분포급여림상특정적관계。방법장275례CRC환자분별안성별、년령、간전이、복수、장류직경、장류위치、혈편、을간진행분조，총결분석환자혈청CEA、CA199적농도균치、양성솔급여림상특정적관계。결과반간전이，종류위우결장，유혈편，유복수적CRC환자중혈청CEA、CA199적농도균치균명현승고，차이유통계학의의（ P＜0．05）。이혈청CEA、CA199적수평여성별、년령、장류직경、을간무명현상관성（ P＞0．05）。결론혈청CEA、CA199가작위조기진단결직장암간전이적일충유효방법，엄범적용우림상。
Objective To discuss the relationship between serum CEA , CA199 distribution and clinical features in advanced colorectal cancer .Methods 275 colorectal cancer patients were classified into groups according to gender ,age ,liver metastases,ascites,intestinal tumor diameter,intestinal tumor location, bloody stools ,and hepatitis B .Retrospectively analyze the relationship between serum CEA ,CA199 and those groups applying χ2and t-test.Results The mean serufm CEA,CA199 concentrations in CRC patients with liver metastasis,tumor in colon,bloody stools,ascites were significantly increased,and the difference was statistically significant(P<0.05),while there is no correlation with gender,age,intestinal tumor diameter,or hepatitis B(P>0.05).Conclusions Serum CEA,CA199 can be used as an early and effective diagnosis of colorectal cancer patients with liver metastases and should be widely used in clinical practice .