CAJ | 학술논문

成人生长激素缺乏症可致机体组分改变、糖、脂代谢紊乱、骨代谢异常、心血管疾病风险增加及生活质量下降等,生长激素替代治疗可有效改善以上情况.但生长激素广泛的生理作用使其安全性备受争议,近几年大部分文献提示生长激素替代治疗不增加糖尿病的发生、肿瘤复发、新发恶性肿瘤及心血管事件等,但仍缺乏大量随机、对照研究,故在生长激素治疗时应严密监测血清胰岛素样生长因子-1水平、血脂、血压、血糖、骨密度、肿瘤标志物及生活质量等指标.
성인생장격소결핍증가치궤체조분개변、당、지대사문란、골대사이상、심혈관질병풍험증가급생활질량하강등,생장격소체대치료가유효개선이상정황.단생장격소엄범적생리작용사기안전성비수쟁의,근궤년대부분문헌제시생장격소체대치료불증가당뇨병적발생、종류복발、신발악성종류급심혈관사건등,단잉결핍대량수궤、대조연구,고재생장격소치료시응엄밀감측혈청이도소양생장인자-1수평、혈지、혈압、혈당、골밀도、종류표지물급생활질량등지표.
Adult growth hormone deficiency causes a series of abnormities including abnormal body composition,impaired glucose and lipid metabolism,abnormal bone metabolism,as well as increased cardiovascular risk and decreased living quality.Growth hormone replacement therapy can effectively improve those abnormalities.However,the safety of growth hormone is controversial since growth hormone has extensively physiological functions.In recent years,most of the studies revealed that the incidence of diabetes mellitus,tumor recurrence,second neoplasms and cardiovascular events in growth hormone replacement therapy did not increase,although large randomized controlled studies are needed to reach the conclusion.Serum insulin-like growth factor-1 level,serum lipids,blood pressure,plasma glucose,bone mineral density,cancer biomarkers and living quality should be closely monitored during the period of growth hormone replacement therapy.